Results 51 to 60 of about 29,752 (188)

Activity Based Anorexia as an Animal Model for Anorexia Nervosa–A Systematic Review [PDF]

, 2019
Anorexia nervosa (AN) is a severe eating disorder affecting around 1 per 100 persons. However, the knowledge about its underlying pathophysiology is limited.
Schalla, Martha A., Stengel, Andreas
core   +1 more source

Anxiolytic-like effects of antisauvagine-30 in mice are not mediated by CRF2 receptors. [PDF]

PLoS ONE, 2013
The role of brain corticotropin-releasing factor type 2 (CRF2) receptors in behavioral stress responses remains controversial. Conflicting findings suggest pro-stress, anti-stress or no effects of impeding CRF2 signaling.
Eric P Zorrilla, Amanda J Roberts, Jean E Rivier, George F Koob   +3 more
doaj   +1 more source

Incentive learning underlying cocaine relapse requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons [PDF]

, 2010
Understanding the psychobiological basis of relapse remains a challenge in developing therapies for drug addiction. Relapse in cocaine addiction often occurs following exposure to environmental stimuli previously associated with drug taking.
Bilbao, Ainhoa, Chai, Minqiang, Crombag, Hans, Engblom, David, Halbout, Briac, Novak, Martin, O'Connor, Eoin, Parkitna, Jan Rodriguez, Schütz, Günther, Spanagel, Rainer, Stephens, David N, Su, Tian   +11 more
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Forebrain CRF₁ modulates early-life stress-programmed cognitive deficits. [PDF]

, 2011
Childhood traumatic events hamper the development of the hippocampus and impair declarative memory in susceptible individuals. Persistent elevations of hippocampal corticotropin-releasing factor (CRF), acting through CRF receptor 1 (CRF₁), in ...
Baram, Tallie Z, Deussing, Jan M, Holsboer, Florian, Kraev, Igor, Liebl, Claudia, Müller, Marianne B, Rammes, Gerhard, Rice, Courtney J, Scharf, Sebastian H, Schmidt, Mathias V, Stewart, Michael G, Wang, Xiao-Dong, Wolf, Miriam, Wurst, Wolfgang   +13 more
core   +1 more source

Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: pharmacological and behavioral genetics evidence. [PDF]

, 2012
Considerable evidence suggests that transmission at hypocretin-1 (orexin-1) receptors (Hcrt-R1) plays an important role in the reinstatement of extinguished cocaine-seeking behaviors in rodents.
Fowler, Christie D, Hollander, Jonathan A, Kenny, Paul J, Pham, Don   +3 more
core   +3 more sources

Corticotropin Releasing Factor in the Bed Nucleus of the Stria Terminalis in Socially Defeated and Non-stressed Mice with a History of Chronic Alcohol Intake

Frontiers in Pharmacology, 2017
Stress exposure has been identified as one risk factor for alcohol abuse that may facilitate the transition from social or regulated use to the development of alcohol dependence.
Lucas Albrechet-Souza, Thiago W. Viola, Rodrigo Grassi-Oliveira, Klaus A. Miczek, Rosa M. M. de Almeida   +4 more
doaj   +1 more source

Distribution of Urocortins and Corticotropin-Releasing Factor Receptors in the Cardiovascular System

International Journal of Endocrinology, 2012
Urocortins are human homologues of urotensin I, a fish corticotropin-releasing-factor- (CRF-) like peptide secreted from the urophysis. There are three urocortins: urocortin 1, urocortin 2, and urocortin 3 in mammals.
Kazuhiro Takahashi
doaj   +1 more source

Hyperactivity of Hypothalamic-Pituitary-Adrenal Axis Due to Dysfunction of the Hypothalamic Glucocorticoid Receptor in Sigma-1 Receptor Knockout Mice

Frontiers in Molecular Neuroscience, 2017
Sigma-1 receptor knockout (σ1R-KO) mice exhibit a depressive-like phenotype. Because σ1R is highly expressed in the neuronal cells of hypothalamic paraventricular nuclei (PVN), this study investigated the influence of σ1R deficiency on the regulation of ...
Tingting Di, Tingting Di, Suyun Zhang, Juan Hong, Juan Hong, Tingting Zhang, Ling Chen, Ling Chen   +7 more
doaj   +1 more source

Corticotropin-releasing hormone as the homeostatic rheostat of feto-maternal symbiosis and developmental programming In utero and neonatal life [PDF]

, 2017
A balanced interaction between the homeostatic mechanisms of mother and the devel- oping organism during pregnancy and in early neonatal life is essential in order to ensure optimal fetal development, ability to respond to various external and internal ...
Alcantara-Alonso, Alexander, Arborelius, Bale, Baram, Barker, Bellisario, Benjamin Neelon, Bosch, Bouret, Bowman, Briana, Brummelte, Brunson, Brunton, Brunton, Brunton, Brunton, Capron, Chen, Chen, Choy, Cirulli, Cirulli, Class, Clifton, Cottrell, Dallman, Davis, de Weerth, Demendi, Desai, Dimasuay, Dunkel, D’Amato, Eghbal-Ahmadi, Ehlers, Ellman, Entringer, Fasting, Faturi, Fenoglio, Gao, Gillman, Glynn, Gomez-Roig, Grammatopoulos, Gunnar, Harville, Hollrigel, Husum, Ibanez, Kammerer, Kensara, Korosi, Labonte, Ladyman, Larsen, Lee, Lockwood, Machado, MacKay, Maffeis, Magiakou, Maniam, Marciniak, McLean, Mingrone, Owens, Pasquali, Paternain, Pedersen, Pelleymounter, Peng, Perrone, Pervanidou, Petraglia, Pihoker, Plotsky, Purcell, Robinson, Romens, Sanchez, Sandman, Sandman, Schmidt, Schulte, Seckl, Seckl, Sferruzzi-Perri, Shapiro, Singh-Taylor, Smith, Soma-Pillay, Stout, Suderman, Sun, Symonds, Tamashiro, Turecki, van Bodegom, Vazquez, Vickers, Wadhwa, Wakahashi, Walker, Wang, Weaver, Weaver, Weinstock, Whitaker, Whitehead, Wolfe, Yam, Zambrano   +114 more
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Beraprost Sodium, a Stable Analogue of PGI2, Inhibits the Renin-Angiotensin System in the Renal Tissues of Rats with Chronic Renal Failure

Kidney & Blood Pressure Research, 2018
Background/Aims: Chronic renal failure (CRF) is a prolonged kidney condition characterized by decreased kidney function that can eventually develop into total kidney failure.
Xin-Fang Wang, Bei-Hao Zhang, Xiao-Qing Lu, Pei Wang   +3 more
doaj   +1 more source