Results 71 to 80 of about 119,569 (285)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The negative association of low subjective socioeconomic status with future orientation: the protective role of low fatalism

BMC Psychology
Background Subjective socioeconomic status (SES), an individual’s beliefs about his or her social class, is anticipated to be related to future orientation.
Lingling Shu, Tianzi Gong, Yuting Wang, Qinggong Li, Zhiwen Xie   +4 more
doaj   +1 more source

Olfactory sensation emotion regulation: The implicit emotion regulation function of positive olfactory stimuli during emotional picture processing

NeuroImage
Previous research has shown that olfactory stimuli can induce emotional states, physiological and neural responses related to emotions. It remains unclear whether positive olfactory stimuli could down-regulate individuals’ negative emotions or up ...
Jiaotao Cai, Xinran Wang, Jiayi Zhou, Ye di, Ziruo Shen, Shuo An, Bingyang Long, Yicheng Wang, Zitong Li, Yiting Li, Si Chen, Yanmei Wang   +11 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Parafoveal Processing of Orthography, Phonology, and Semantics during Chinese Reading: Effects of Foveal Load

Brain Sciences
The foveal load hypothesis assumes that the ease (or difficulty) of processing the currently fixated word in a sentence can influence processing of the upcoming word(s), such that parafoveal preview is reduced when foveal load is high.
Lei Zhang, Liangyue Kang, Wanying Chen, Fang Xie, Kayleigh L. Warrington   +4 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Dynamic brain networks in spontaneous gestural communication

npj Science of Learning
Gestures accent and illustrate our communication. Although previous studies have uncovered the positive effects of gestures on communication, little is known about the specific cognitive functions of different types of gestures, or the instantaneous ...
Xinyue Wang, Kelong Lu, Yingyao He, Xinuo Qiao, Zhenni Gao, Yu Zhang, Ning Hao   +6 more
doaj   +1 more source

Commentary on Gelberg et al. 2015: Alcohol and other drug screening and brief intervention – evidence in crisis [PDF]

, 2015
Richard Saitz
openalex   +1 more source