Results 191 to 200 of about 1,254,871 (374)
Novel CRISPR/Cas applications in plants: from prime editing to chromosome engineering [PDF]
, 2021 Teng‐Kuei Huang, Holger Puchta
openalex +1 more source
RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy
Advanced Science, EarlyView.This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu +12 more
wiley +1 more source
Mechanism for Cas4-assisted directional spacer acquisition in CRISPR–Cas
, 2021 Chunyi Hu +8 more
openalex +2 more sources
CRISPR-Cas systems for editing, regulating and targeting genomes
Nature Biotechnology, 2014 Jeffry D. Sander, J. Joung
semanticscholar +1 more source
CRISPR-Cas systems in enterococci
Brazilian Journal of MicrobiologyEnterococci are members of the microbiota of humans and other animals. They can also be found in the environment, associated with food, healthcare infections, and hospital settings. Due to their wide distribution, they are inserted in the One Health context.
Amanda Seabra Cabral +8 more
openaire +2 more sources
The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation
Advanced Science, EarlyView.ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley +1 more source
A practical guide for characterization of novel CRISPR-Cas systems with Pro-CRISPR factors [PDF]
Ao Sun, Shu-Lin Jin, Junjie Liu
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Publisher Correction: Structural basis of DNA targeting by a transposon-encoded CRISPR–Cas system [PDF]
, 2020 Tyler S. Halpin-Healy +3 more
openalex +1 more source
Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques
Advanced Science, EarlyView.Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang +12 more
wiley +1 more source