Results 191 to 200 of about 54,706 (289)

CRISPR-Cas systems: Overview, innovations and applications in human disease research and gene therapy

, 2020
Yuanyuan Xu, Zhanjun Li
openalex   +1 more source

Pan‐3D Genome Analysis Reveals the Roles of Structural Variation in Chicken Chromatin Architectures, Domestication and Production Traits

Advanced Science, EarlyView.
This study firstly presents a comprehensive and high‐resolution pan‐3D genome resource in chicken. Our findings reveal the role of structural variations in 3D genome architectures, and how they influence the domestication process and production traits at the 3D genome level.
Zhen Zhou, Danfeng Cai, Changbin Zhao, Siyu Zhang, Jiahao Li, Zhaofeng Zhang, Shaofen Kong, Xin Yang, Xiaoli Zhou, Farhad Bordbar, Fayi Chen, Yaohuan Xu, Zhe Zhang, Lihong Gu, Zhenhui Li, Xiquan Zhang, Wen Luo, Jingting Shu, Bolin Cai, Qinghua Nie   +19 more
wiley   +1 more source

Structural basis of Cas8-independent Cas3 recruitment in Type I-F2 CRISPR-Cas. [PDF]

Nucleic Acids Res
Perry TN, Mais CN, Sanchez-Londono M, Steinchen W, Plitzko PA, Randau L, Pausch P, Innis CA, Bange G.   +8 more
europepmc   +1 more source

CRISPR–Cas protection from plant viruses [PDF]

, 2015
Eytan Zlotorynski
openalex   +1 more source

The Maize ZmbHLH118 Transcription Factor Regulates Vacuolar Nitrate Loading by the NO3− Transporter ZmCLCa

Advanced Science, EarlyView.
In maize, the bHLH transcription factor ZmbHLH118 directly binds to the promoter of ZmCLCa and inhibits its expression. Tonoplast‐localized ZmCLCa mediates NO3− influx into the vacuole to regulate intracellular NO3− homeostasis, modulating nitrate uptake and metabolism, plant growth, and grain yield.
Chaonan Zhang, Elsa Demes‐Causse, Xujian Li, Zhenhui Guo, Hanshu Zhao, Huairong Cao, Yajing Song, Lijun Mu, Kaikai Zhang, Jing Zhang, Zhongtao Jia, Lixing Yuan, Alexis De Angeli, Jingbo Zhang   +13 more
wiley   +1 more source

CRISPR-Cas Technology Turns Chlamydomonas reinhardtii into a Flagship for Algal Biotechnology. [PDF]

Mar Drugs
Antonacci A, Masi A, Vedi V, Colella S, Musella F, Fiorentino G, Scognamiglio V.   +6 more
europepmc   +1 more source

Efficient, compact, and versatile: Type I‐F2 CRISPR‐Cas system [PDF]

Shengsheng Ma, Senfeng Zhang, K. Liu, Tao Hu, Chunyi Hu   +4 more
openalex   +1 more source

Dual‐Key Genetic Circuit Enables Stable and Self‐Regulated Engineered Bacteria for the Treatment of Ulcerative Colitis

Advanced Science, EarlyView.
A self‐regulated Escherichia coli Nissle 1917 strain equipped with a dual‐key genetic circuit achieved antibiotic‐free stability and programmable lysis for therapeutic protein delivery. By co‐expressing an IL‐2 mutant and Amuc_1100, the engineered bacteria restored immune balance and epithelial integrity, providing a safe and precise approach for ...
Shuaijie Ding, Biao Yang, Xinyu Li, Yi Wang, Chunyu Huang, Wenfei Dong, Wei Xie   +6 more
wiley   +1 more source

Systematically Engineering for Efficient Production of 3‐Methyl‐1‐Butanol in Escherichia coli

Advanced Science, EarlyView.
An integrated metabolic engineering strategy was established for high‐level 3‐methyl‐1‐butanol biosynthesis in Escherichia coli. Molecular dynamics‐guided semi‐rational engineering of dihydroxyacid dehydratase uncovered and relieved key catalytic bottlenecks, while adaptive laboratory evolution enhanced strain robustness.
Nanfei Geng, Hao Liu, Haolin Han, Meng Meng, Shaojie Wang, Tianwei Tan, Haijia Su   +6 more
wiley   +1 more source

LysR-type regulator LrhA promotes CRISPR-Cas immunity in Escherichia coli. [PDF]

Nucleic Acids Res
Fang M, Yap J, Fei M, Gong M, Li N, Lu Y, Yu M, Xu Y, Wu F, Gao H, Sun D.   +10 more
europepmc   +1 more source