Results 221 to 230 of about 1,254,871 (374)

The next generation of CRISPR–Cas technologies and applications

Nature reviews. Molecular cell biology, 2019
Adrian Pickar-Oliver, C. Gersbach
semanticscholar   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Occurrence and applications of CRISPR-Cas systems in bifidobacteria. [PDF]

Appl Environ Microbiol
Shin J, Barrangou R.
europepmc   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

CRISPR-Cas-Mediated Reprogramming Strategies to Overcome Antimicrobial Resistance. [PDF]

Pharmaceutics
Yoon B, Kim JA, Kang YK.
europepmc   +1 more source

Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System [PDF]

, 2017
Yibei Xiao, Min Luo, Robert P. Hayes, Jonathan Kim, Sherwin Ng, Fang Ding, Maofu Liao, Ailong Ke   +7 more
openalex   +1 more source

Review on Anti-Biofilm Potential of CRISPR-Cas System on Various Pathogens

, 2023
Tamalika Chakraborty, Sumana Chatterjee, Lopamudra Datta, Ranjana Shaw   +3 more
openalex   +1 more source

Diversity and evolution of class 2 CRISPR–Cas systems

Nature Reviews Microbiology, 2017
Sergey A. Shmakov, A. Smargon, David A. Scott, David B. T. Cox, N. Pyzocha, Winston X. Yan, Omar O. Abudayyeh, J. Gootenberg, K. Makarova, Y. Wolf, K. Severinov, Feng Zhang, E. Koonin   +12 more
semanticscholar   +1 more source

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source

Anoxia activates CRISPR-Cas immunity in the mouse intestine. [PDF]

Nat Microbiol
Campbell IW, Basta DW, Zingl FG, Sullivan EJ, Doranga S, Waldor MK.   +5 more
europepmc   +1 more source