Results 231 to 240 of about 80,955 (297)

CRISPR-Cas based plasmid design for multidrug-resistant Klebsiella pneumoniae isolates. [PDF]

FEMS Microbiol Lett
Baba S, Oncul O, Aktas Z.
europepmc   +1 more source

Antiviral CRISPR-Cas strategies

Combination antiretroviral therapy (cART) can effectively inhibit replication of the human immunodeficiency virus (HIV) and prevent progression to AIDS. However none of the currently available drugs inactivate the HIV DNA that is integrated on one of the chromosomes of all infected cells.
openaire   +1 more source

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

Advanced Science, EarlyView.
Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu, Bayinqiaoge, Xi Lu, Xin Wang, Rongfeng Wang, Yi Li, Shi‐Yang Tang, Chengchen Zhang   +7 more
wiley   +1 more source

Chronic In Vivo CRISPR-Cas Genome Editing: Challenges, Long-Term Safety, and Outlook. [PDF]

Cells
Bao C, Channell CI, Tseng YH, Bailey J, Sbaiti N, Demirkol A, Tsang SH.   +6 more
europepmc   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Diversity of CRISPR-Cas Systems Identified in Urological <i>Escherichia coli</i> Strains. [PDF]

Microorganisms
Slukin PV, Fursov MV, Volkov DV, Sizova AA, Detushev KV, Dyatlov IA, Fursova NK.   +6 more
europepmc   +1 more source

Transposase‐Assisted Donor Tethering Boosts Large‐Fragment HDR in Plants

Advanced Science, EarlyView.
A transposase‐assisted donor tethering strategy is developed to enhance homology‐directed repair in plants. By recruiting donor DNA to double‐strand breaks and synergizing with repair pathway reprogramming and transcription‐coupled donor design, this system markedly improves large‐fragment targeted insertion efficiency, providing a robust platform for ...
Sha Wei, Kai Zhang, Shuke Deng, Jinjie Chen, Xiaomei Huang, Jingfei Guo, Yuqing Wu, Yingjie Guo, Zhen Liang   +8 more
wiley   +1 more source

Status and advancement of root-knot nematode management strategies and the emerging CRISPR/Cas biotechnology application. [PDF]

Funct Integr Genomics
Pan X, Yildiz U, Armstrong SK, Bissonnette K.   +3 more
europepmc   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Programmable molecular microscopy: CRISPR/Cas fluorescent probes revolutionizing spatiotemporal genomic imaging. [PDF]

Theranostics
Zhong XY, Yang YX, Xiong YF, Ye GC, Gong X, Zhong ML, He HD, Wang SG, Xia QD.   +8 more
europepmc   +1 more source