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Biologie in unserer Zeit, 2013
AbstractEiner der ältesten Konflikte auf Erden ist vermutlich der Existenzkampf zwischen Prokaryoten und Viren. Prokaryoten haben verschiedene Abwehrstrategien entwickelt, um sich gegen die allgegenwärtigen und zahlenmäßig überlegenen Viren zu schützen. Letztere besitzen wiederum Gegenmechanismen, mit denen sie den prokaryotischen Schutz umgehen.
Anita Marchfelder +3 more
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AbstractEiner der ältesten Konflikte auf Erden ist vermutlich der Existenzkampf zwischen Prokaryoten und Viren. Prokaryoten haben verschiedene Abwehrstrategien entwickelt, um sich gegen die allgegenwärtigen und zahlenmäßig überlegenen Viren zu schützen. Letztere besitzen wiederum Gegenmechanismen, mit denen sie den prokaryotischen Schutz umgehen.
Anita Marchfelder +3 more
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MicroRNA Detection with CRISPR/Cas
2023Low-cost detection of miRNAs has caught broad attention in recent years due to the potential application of these small noncoding RNAs for diagnostics and therapeutic purposes. Their small size and low abundance, however, derive challenges in engineering robust detection tools.
Xinyuan, Qiu +3 more
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Journal of Cellular Physiology, 2020
AbstractClustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated enzyme (Cas) is a naturally occurring genome editing tool adopted from the prokaryotic adaptive immune defense system. Currently, CRISPR/Cas9‐based genome editing has been becoming one of the most promising tools for treating human genetic diseases, including ...
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AbstractClustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated enzyme (Cas) is a naturally occurring genome editing tool adopted from the prokaryotic adaptive immune defense system. Currently, CRISPR/Cas9‐based genome editing has been becoming one of the most promising tools for treating human genetic diseases, including ...
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CRISPR–Cas in the laboratory classroom
Nature Microbiology, 2017CRISPR–Cas is an adaptive immune system found in Bacteria and Archaea that confers sequence-specific protection against invasion by foreign nucleic acids. CRISPR–Cas is also a powerful tool for microbiology education and has been an inspiring model for our students for the past three years.
Luc, Trudel +2 more
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CRISPR-Cas immunity in prokaryotes
Nature, 2015Prokaryotic organisms are threatened by a large array of viruses and have developed numerous defence strategies. Among these, only clustered, regularly interspaced short palindromic repeat (CRISPR)-Cas systems provide adaptive immunity against foreign elements. Upon viral injection, a small sequence of the viral genome, known as a spacer, is integrated
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Nature Reviews Molecular Cell Biology, 2019
CRISPR–Cas9-based prime editing supports the correction of a wide range of mutations, including transversions and insertions and deletions.
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CRISPR–Cas9-based prime editing supports the correction of a wide range of mutations, including transversions and insertions and deletions.
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Staying on target with CRISPR-Cas
Nature Biotechnology, 2013Four independent studies shed light on the specificity of RNA-guided genome editing tools based on the Streptococcus pyogenes Cas9 protein.
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Structural biology of CRISPR–Cas immunity and genome editing enzymes
Nature Reviews Microbiology, 2022Joy Y Wang +2 more
exaly
2013
Discovery and seminal developments in the CRISPR field.- Occurrence, diversity of CRISPR-Cas systems and genotyping implications.- Evolution and classification of CRISPR-Cas systems and Cas protein families.- Regulation of CRISPR-based immune responses.- crRNA Biogenesis.- Distribution and mechanism of the Type I CRISPR/Cas Systems.- Type II ...
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Discovery and seminal developments in the CRISPR field.- Occurrence, diversity of CRISPR-Cas systems and genotyping implications.- Evolution and classification of CRISPR-Cas systems and Cas protein families.- Regulation of CRISPR-based immune responses.- crRNA Biogenesis.- Distribution and mechanism of the Type I CRISPR/Cas Systems.- Type II ...
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