Results 31 to 40 of about 1,216,536 (293)

CRISPR RNA biogenesis by a Cas6 nuclease [PDF]

, 2015
Clustered regularly interspaced short palindromic repeats (CRISPRs) and associated (Cas) proteins form the basis of a prokaryotic adaptive immune system.
Sokolowski, Richard D.
core   +2 more sources

Associate toxin-antitoxin with CRISPR-Cas to kill multidrug-resistant pathogens

Nature Communications, 2023
CreTA, CRISPR-regulated toxin-antitoxin (TA), safeguards CRISPR-Cas immune systems by inducing cell dormancy/death upon their inactivation. Here, we characterize a bacterial CreTA associating with the I-F CRISPR-Cas in Acinetobacter.
Rui Wang, Xian Shu, Huiwei Zhao, Qiong Xue, Chao Liu, Aici Wu, Feiyue Cheng, Lingyun Wang, Yihan Zhang, Jie Feng, Nannan Wu, Ming Li   +11 more
doaj   +1 more source

Development and Application of CRISPR/Cas System in Rice

Rice Science, 2019
In the past several years, the CRISPR (clustered regularly interspaced short palindromic repeats)/Cas (CRISPR-associated protein) system has been harnessed as an efficient and powerful tool for targeted genome editing in different prokaryotic and ...
Ren Jun, Hu Xixun, Wang Kejian, Wang Chun   +3 more
doaj   +1 more source

Clustered Regularly Interspaced Short Palindromic Repeats-Associated Protein System for Resistance Against Plant Viruses: Applications and Perspectives

Frontiers in Plant Science, 2022
Different genome editing approaches have been used to engineer resistance against plant viruses. The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas; CRISPR/Cas) systems to create pinpoint genetic ...
Fredy D. A. Silva, Elizabeth P. B. Fontes   +1 more
doaj   +1 more source

Structure of the archaeal Cascade subunit Csa5 : Relating the small subunits of CRISPR effector complexes [PDF]

, 2013
This work was funded by a grant from the Biotechnology and Biological Sciences Research Council (BBSRC) (REF: BB/G011400/1) to M.F.W. and J.H.N. and a BBSRC-funded studentship to J.R.The Cascade complex for CRISPR-mediated antiviral immunity uses CRISPR ...
Naismith, Jim, White, Malcolm F, Anderson, Linzi, Liu, Huanting, Reeks, Judith Anne, Graham, Shirley   +5 more
core   +1 more source

CRISPR-Cas

Revista de Ciência Elementar, 2023
Jorge Canhoto, Sandra Correia, Sílvia Coimbra, Ricardo Ferraz   +3 more
  +5 more sources

Multiple nucleic acid cleavage modes in divergent type III CRISPR systems [PDF]

, 2016
CRISPR-Cas is an RNA-guided adaptive immune system that protects bacteria and archaea from invading nucleic acids. Type III systems (Cmr, Csm) have been shown to cleave RNA targets in vitro and some are capable of transcription-dependent DNA targeting ...
Zhang, Jing, White, Malcolm Frederick, Tello, Agnes, Liu, Huanting, Graham, Shirley   +4 more
core   +1 more source

Intrinsic sequence specificity of the Cas1 integrase directs new spacer acquisition [PDF]

, 2015
This work was supported by a grant from the Biotechnology and Biological Sciences Research Council (REF: BB/M000400/1 to MFW).The adaptive prokaryotic immune system CRISPR-Cas provides RNA-mediated protection from invading genetic elements.
Bolt, Edward, White, Malcolm F., Rollie, C, White, Malcolm F, Anna Sophie Brinkmann, Malcolm F White, Clare Rollie, Edward L Bolt, Brinkmann, Anna Sophie, Rollie, Clare, Bolt, EL, Rollie, Clare Jane Catherine, Schneider, Stefanie, White, MF, Stefanie Schneider, Bolt, Edward L., Schneider, S, Brinkmann, AS   +17 more
core   +1 more source

CRISPR-Cas Controls Cryptic Prophages

, 2022
The bacterial archetypal adaptive immune system, CRISPR-Cas, is thought to be repressed in the best-studied bacterium, Escherichia coli K-12. We show here that the E.
Severinov, Konstantin, Toshinari Maeda, Wood, Thomas K., Toshinari Maeda (76008), Konstantin Severinov, Song, Sooyeon, Sooyeon Song, Konstantin Severinov (11333), Michael J. Benedik (2353612), Michael J. Benedik, Thomas K. Wood, Laura Fernández-García, Maeda, Toshinari, Thomas K. Wood (49042), Ekaterina Semenova, Fernández-García, Laura, Laura Fernández-García (3854878), Ekaterina Semenova (13071), Benedik, Michael J., Semenova, Ekaterina, Sooyeon Song (4891132)   +20 more
core   +1 more source

CRISPR-mediated targeted mRNA degradation in the archaeon Sulfolobus solfataricus [PDF]

, 2014
European SulfoSYS-project [SysMo P–N-01-09-23] and grant [9P23000 and P25369] by the Austrian Research fund (to C.S.) and by grant [BB/K000314/1] from the Biotechnology and Biological Sciences Research Council (to M.F.W.). Funding for open access charge:
Manica, A., Zebec, Z., Schleper, C., Zhang, J., White, M.F.   +4 more
core   +1 more source