Results 31 to 40 of about 50,942 (257)
Viral Diversity Threshold for Adaptive Immunity in Prokaryotes
mBio, 2012 Bacteria and archaea face continual onslaughts of rapidly diversifying viruses and plasmids. Many prokaryotes maintain adaptive immune systems known as clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated genes (Cas ...
Ariel D. Weinberger +4 more
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Application of different types of CRISPR/Cas-based systems in bacteria
Microbial Cell Factories, 2020 As important genome editing tools, CRISPR/Cas systems, especially those based on type II Cas9 and type V Cas12a, are widely used in genetic and metabolic engineering of bacteria.
Zhenquan Liu +4 more
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CRISPR-Cas: Adapting to change
Science, 2017 Variation in prokaryote adaptive immunity To repel infection by phage and mobile genetic elements, prokaryotes have a form of adaptive immune response and memory invested in clustered regularly interspaced short palindromic repeats and associated proteins (CRISPR-Cas).
Jackson, Simon A. +5 more
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Research advances on pathogenic nucleic acid detection technology based on CRIPSR/Cas system
浙江大学学报. 农业与生命科学版, 2023 Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) (CRISPR/Cas) system, an ancient bacterial and archaeal immune system, has rapidly developed into a popular gene-editing tool, which largely promotes the ...
LI Hongzhao +4 more
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CRISPR-Cas Systems in Streptococci [PDF]
Current Issues in Molecular Biology, 2019 Streptococci are one of the most important and common constituents of the host's microbiota and can colonize and live in the upper respiratory and urogenital tract of humans and animals. The CRISPR-Cas systems (i.e., clustered regularly interspaced short palindromic repeat, with CRISPR-associated proteins) found in bacteria and archaea provide sequence-
Tao, Gong +7 more
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CRISPR-Cas9/Cas12a biotechnology and application in bacteria
Synthetic and Systems Biotechnology, 2018 CRISPR-Cas technologies have greatly reshaped the biology field. In this review, we discuss the CRISPR-Cas with a particular focus on the associated technologies and applications of CRISPR-Cas9 and CRISPR-Cas12a, which have been most widely studied and ...
Ruilian Yao +5 more
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Associate toxin-antitoxin with CRISPR-Cas to kill multidrug-resistant pathogens
Nature Communications, 2023 CreTA, CRISPR-regulated toxin-antitoxin (TA), safeguards CRISPR-Cas immune systems by inducing cell dormancy/death upon their inactivation. Here, we characterize a bacterial CreTA associating with the I-F CRISPR-Cas in Acinetobacter.
Rui Wang +11 more
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Development and Application of CRISPR/Cas System in Rice
Rice Science, 2019 In the past several years, the CRISPR (clustered regularly interspaced short palindromic repeats)/Cas (CRISPR-associated protein) system has been harnessed as an efficient and powerful tool for targeted genome editing in different prokaryotic and ...
Ren Jun +3 more
doaj +1 more source
Frontiers in Plant Science, 2022 Different genome editing approaches have been used to engineer resistance against plant viruses. The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas; CRISPR/Cas) systems to create pinpoint genetic ...
Fredy D. A. Silva +1 more
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The CRISPR-Cas system in Enterobacteriaceae [PDF]
Pathogens and Disease, 2018 In nature, microorganisms are constantly exposed to multiple viral infections and thus have developed many strategies to survive phage attack and invasion by foreign DNA. One of such strategies is the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas) bacterial immunological system.
Liliana, Medina-Aparicio +4 more
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