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Recent Advances in Genome Editing Using CRISPR/Cas9
Frontiers in Plant Science, 2016 The CRISPR (clustered regularly interspaced short palindromic repeat)-Cas9 (CRISPR-associated nuclease 9) system is a versatile tool for genome engineering that uses a guide RNA (gRNA) to target Cas9 to a specific sequence.
Yuduan eDing +6 more
doaj +1 more source
The tsunami named CRISPR/Cas9 [PDF]
Revue Neurologique, 2018 It is rare to witness a breakthrough technology that results in a multidimensional revolution in human health that also has impacts on animals and plants as well as biodiversity and the environment. The tsunami associated with the latest genome editing techniques is most likely not comparable to anything we have known thus far.
openaire +3 more sources
From RNA to DNA: How Cargo Identity Reprograms Lipid Nanoparticle Architecture and Function
Advanced Healthcare Materials, EarlyView.The evolution of lipid nanoparticles (LNPs) spans from RNA‐LNPs, used in mRNA vaccines, to DNA‐LNPs, ideal for gene therapies. Emerging bionano architectures, decorated with DNA and plasma proteins, pave the way for advanced DNA‐based therapies that are more stable, targeted, and customizable.
Erica Quagliarini +2 more
wiley +1 more source
Genes and DiseasesCRISPR/Cas9 is an effective gene editing tool with broad applications for the prevention or treatment of numerous diseases. It depends on CRISPR (clustered regularly interspaced short palindromic repeats) as a bacterial immune system and plays as a gene ...
Mohadeseh Khoshandam +4 more
doaj +1 more source
CRISPR/Cas9: Prospects and Challenges [PDF]
Human Gene Therapy, 2015 All science takes inspiration from nature, but nowhere is this more true than in biology, where some of the most powerful tools available to researchers are derived from natural products. From restriction enzymes and fluorescent proteins to microbial opsins and viral gene delivery vectors, researchers have capitalized on processes that occur in a ...
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Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration
Advanced Healthcare Materials, EarlyView.Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu +4 more
wiley +1 more source
Engineering CRISPR/Cas9 therapeutics for cancer precision medicine
Frontiers in GeneticsThe discovery of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated protein 9 (Cas9) technology has revolutionized field of cancer treatment.
Aditya Kumar Sharma +2 more
doaj +1 more source
Reshuffling yeast chromosomes with CRISPR/Cas9
PLOS Genetics, 2019 Genome engineering is a powerful approach to study how chromosomal architecture impacts phenotypes. However, quantifying the fitness impact of translocations independently from the confounding effect of base substitutions has so far remained challenging.
Aubin Fleiss +7 more
openaire +5 more sources
Advanced Materials, EarlyView.A cryoprotectant‐compatible nanoporous platform enables ambient‐stable and scalable delivery of gene editing therapeutics. By combining hierarchical pore architecture with optimized lyophilization chemistry, the system preserves Cas9‐RNP activity post‐freeze‐drying.
Sian Lee +8 more
wiley +1 more source
Targeted mutagenesis of FaTM6 in the Octoploid Strawberry (Fragaria x ananassa) using the CRISPR/Cas9 System [PDF]
, 2018 The B-class of MADS-box transcription factors has been studied in many plant species, but remain functionally uncharacterized in the Rosaceae family.
Duarte-Conde, José Antonio +2 more
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