Results 131 to 140 of about 259,520 (336)
Advanced Materials, EarlyView.Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode +16 more
wiley +1 more source
Engineering CRISPR/Cas9 therapeutics for cancer precision medicine
Frontiers in GeneticsThe discovery of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated protein 9 (Cas9) technology has revolutionized field of cancer treatment.
Aditya Kumar Sharma +2 more
doaj +1 more source
Reshuffling yeast chromosomes with CRISPR/Cas9
PLOS Genetics, 2019 Genome engineering is a powerful approach to study how chromosomal architecture impacts phenotypes. However, quantifying the fitness impact of translocations independently from the confounding effect of base substitutions has so far remained challenging.
Aubin Fleiss +7 more
openaire +5 more sources
Two‐Photon 3D Printing of Functional Microstructures Inside Living Cells
Advanced Materials, EarlyView.This study demonstrates 3D printing inside living cells by using two‐photon photo‐lithography. A bio‐compatible photoresist is injected into cells and selectively polymerized with a femtosecond laser, creating custom‐shaped intracellular structures with submicron resolution.
Maruša Mur +4 more
wiley +1 more source
The prospects of gene therapy for mitochondrial diseases: can’t we do without CRISPR/Cas9? [PDF]
, 2017 Ivan Chicherin +4 more
openalex +1 more source
Advanced Science, EarlyView.YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang +8 more
wiley +1 more source
NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction
Advanced Science, EarlyView.NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu +15 more
wiley +1 more source
Advanced Science, EarlyView.Spermatogonial stem cells (SSCs) provide critical support to spermatogenesis. Here, the author established Il1r2 as a sorting marker for SSCs, with which further insights into the SSC heterogeneity and dynamic features can be obtained. They also confirmed findings in both mouse and human, thus validating IL1R2 as the surface marker for isolating and ...
Pengyu Li +19 more
wiley +1 more source
Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration
Advanced Science, EarlyView.Through a genetic screen, PKN2 and MOB4 are identified as two proteins regulating the healing of an epithelial model wound. PKN2 promotes collective cell migration by maintaining the cohesion of cell monolayers from their lateral junctions, whereas MOB4 restrains collective cell migration and provides a lamellipodial cue for front‐rear polarity in ...
Artem I. Fokin +7 more
wiley +1 more source
LNK suppresses interferon signaling in melanoma. [PDF]
, 2019 LNK (SH2B3) is a key negative regulator of JAK-STAT signaling which has been extensively studied in malignant hematopoietic diseases. We found that LNK is significantly elevated in cutaneous melanoma; this elevation is correlated with hyperactive ...
Ding, Ling-Wen +19 more
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