Results 181 to 190 of about 259,520 (336)

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

Advanced Science, EarlyView.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang, Ying Hu, Yang Teng, Jiwei Qi, Yangzhen Ciren, Lin Zhang, Qiao Du, Wencai Xu, Liang Zhou, Zhenxin Fan, Jinchuan Xing, Ming Li, Jing Li   +12 more
wiley   +1 more source

CRISPR-Cas9 knockout screen informs efficient reduction of the Komagataella phaffii secretome [PDF]

Neil C. Dalvie, Timothy Lorgeree, Yuchen Yang, Sergio A. Rodriguez‐Aponte, Charles A. Whittaker, Joshua A. Hinckley, John J Clark, Amanda Del Rosario, Kerry R. Love, J. Christopher Love, J. Christopher Love   +10 more
openalex   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Engineered AcrIIA5 for optogenetic control of CRISPR-Cas9-based genome editing. [PDF]

mLife
Chen Q, Yao J, Lu Y, Qiu R, Deng Z, Sun Y.   +5 more
europepmc   +1 more source

State‐of‐the‐art CRISPR/Cas9 Technology for Genome Editing in Trypanosomatids

, 2019
Noelia Lander, Miguel Ángel Chiurillo
openalex   +2 more sources

Domestication of Tartary Buckwheat Shaped a Regulatory Module for Seedling Salt Tolerance by Targeting the Magnesium Transporter Gene FtMGT2

Advanced Science, EarlyView.
Domestication of Tartary buckwheat is selected for a salt tolerance mechanism involving the magnesium transporter FtMGT2. Its expression is controlled by the FtAGL16‐FtMYB15L module, which is stabilized under salt stress through a competitive interaction that blocks its degradation by the E3 ligase FtBRG1, ultimately boosting Na⁺ efflux and plant ...
Xiang Lu, Yuqi He, Wenfeng Weng, Zebin Liu, Yuanfen Gao, Yaliang Shi, Wei Li, Dili Lai, Mengyu Zhao, Rintu Jha, Hui Zhao, Guangsheng Li, Chaonan Guan, Shuai Shao, Jingjun Ruan, Sun Hee Woo, Yinan Ouyang, Muriel Quinet, Milen I. Georgiev, Alisdair R. Fernie, Congcong Hou, Kaixuan Zhang, Xu Liu, Meiliang Zhou   +23 more
wiley   +1 more source

Suppression of HBV replication and expression by CRISPR/Cas9 ribonucleoproteins. [PDF]

Antiviral Res
Hill AC, Schank MB, Zhang Y, Sun N, Wang L, Zhao J, Banik P, Pyburn JS, Orfield H, Lightner JW, Leshaodo TO, Wu XY, Ning S, El Gazzar M, Moorman JP, Guo H, Yao ZQ.   +16 more
europepmc   +1 more source

Discovering novel antimicrobials from Streptomyces formicae, a symbiont of fungus farming plant ants, using CRISPR/Cas9 genome editing

, 2019
Rebecca Devine, Zhiwei Qin, Barrie Wilkinson, Matt Hutchings   +3 more
openalex   +1 more source

CRISPR-Cas9 Modified iPSC-CAR-NK Cell for Lymphoma Cancer Treatment

, 2021
Ellen Li
openalex   +1 more source