Results 201 to 210 of about 243,751 (303)

Design and transfection of CRISPR/Cas9 constructs for the myostatin gene in Labeo rohita muscle cells. [PDF]

Sci Rep
Iqbal G, Pinto N, Pawaskar D, Sonwane AA, Rasal KD, Singh LS, Chikkathimmashetty NN, Goswami M.   +7 more
europepmc   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

CRISPR-Cas9

Farumashia, 2018
openaire   +1 more source

Upper bound on the mutational burden imposed by a CRISPR-Cas9 gene-drive element. [PDF]

G3 (Bethesda)
Overton MS, Guy SE, Chen X, Martsul A, Carolino K, Akbari OS, Meyer JR, Kryazhimskiy S.   +7 more
europepmc   +1 more source

ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites

Advanced Science, EarlyView.
ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng, Peiyuan Chai, Xiayuhe Pei, Yiwen Chen, Xiaoshuai Huang, Bei Liu, Yiqian Wu, Junlin Teng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Development of low-prolamin rice germplasm via CRISPR/Cas9 editing to improve eating and cooking quality. [PDF]

J Integr Plant Biol
Chen Z, Chen Y, Wan G, Dong H, Pan T, Yang W, Zhou Y, Luo B, Zhu Y, Han X, Lu L, Wang X, Lei C, Zhao Z, Wang J, Ren Y, Wan J.   +16 more
europepmc   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Human pluripotent stem cell engineering with CRISPR-Cas9 for Parkinson's disease. [PDF]

Exp Mol Med
Park SB, Kim JS, Ha Y, Kim MS, Kim TW.
europepmc   +1 more source

CRISPR rendszer optimalizálása Aspergillus fumigatus-ban

Munkám célja olyan univerzálisan alkalmazható CRISPR/Cas9 rendszer elkészítése volt, mellyel hatékonyan lehet géneket kiütni eukarióta élőlényekben. A konstrukciómmal egyúttal a CRISPR/Cas9 rendszer hatékonyságát is növelni szerettem volna, hogy kevesebb
Szikora, Péter
core  

TED1 Promotes the Assembly of SCFD3‐D14‐D53 to Reinforce Strigolactone Signaling in Rice

Advanced Science, EarlyView.
This study identifies TED1 as a positive regulator of strigolactones (SL) signaling in rice. The ted1 mutants display dwarfism and increased tillering with significantly reduced SLs sensitivity. Through its longer C‐terminal region, TED1 interacts with D53 and D14 to promote the assembly of SCFD3‐D14‐D53, thereby facilitating the efficient ...
Sheng Luo, Chuanyin Wu, Miao Feng, Wenfan Luo, Rong Miao, Jinsheng Qian, Fan Wang, Chunlei Zhou, Bojuan Liu, Jiale Shao, Ziqi Xun, Yehui Xiong, Zhichao Zhao, Cailin Lei, Shanshan Zhu, Yulong Ren, Xin Wang, Xiuping Guo, Haiyang Wang, Zichao Li, Zhijun Cheng, Qibing Lin, Jianmin Wan   +22 more
wiley   +1 more source