Results 211 to 220 of about 216,936 (304)

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

Advanced Science, EarlyView.
Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan, Yongjie Huang, Jiabao Yang, Su Ma, Songsong Liu, Xuan Huang, Juergen Brosius, Huaping Zheng, Bing Yao, Li Chen, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

CRISPR/Cas9-mediated miR-21 editing in high-grade urothelial carcinoma cells and its biological effects. [PDF]

Mol Biol Rep
Yi Lin Lee MC, Camargo JA, Caetano Vilas Boas G, Silva KS, Silva LP, Mioshi CM, Pimenta R, Silva IA, Ramos Moreira Leite K, Nahas WC, Dos Reis ST.   +10 more
europepmc   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Transformasi genetik in planta: Teknik ringkas penghantaran sistem CRISPR/Cas9 ke dalam sel bagi tujuan pengeditan genom padi

Sistem pengeditan genom/gen Clustered Regularly Interspaced Palindromic Repeats (CRISPR)/Cas9 kini diaplikasikan dalam bidang bioteknologi tumbuhan untuk penghasilan tanaman yang disunting secara genetik.
Tamizi, Amin Asyraf, Nazaruddin, Nazrul Hisham, Zainuddin, Zarina, Samsulrizal, Nurul Hidayah, Sekeli, Rogayah   +4 more
core  

Evaluation of CRISPR/Cas9 based single and multiplex gRNAs against ChiLCV in tobacco. [PDF]

J Genet Eng Biotechnol
Sushmitha LC, Srivastava A, Yadav RK, Roy A, Saxena S, Saini N, Jain PK, Behera TK, Mangal M.   +8 more
europepmc   +1 more source

Transposase‐Assisted Donor Tethering Boosts Large‐Fragment HDR in Plants

Advanced Science, EarlyView.
A transposase‐assisted donor tethering strategy is developed to enhance homology‐directed repair in plants. By recruiting donor DNA to double‐strand breaks and synergizing with repair pathway reprogramming and transcription‐coupled donor design, this system markedly improves large‐fragment targeted insertion efficiency, providing a robust platform for ...
Sha Wei, Kai Zhang, Shuke Deng, Jinjie Chen, Xiaomei Huang, Jingfei Guo, Yuqing Wu, Yingjie Guo, Zhen Liang   +8 more
wiley   +1 more source

CRISPR/Cas9-mediated disruption of <i>MdGA20ox</i> confers dwarfism in apple. [PDF]

Hortic Res
Guo N, Huang N, Xiong Y, Chen D, Sun H, Yang Q, Zhang H, Wang Y, Han Z, Li W.   +9 more
europepmc   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

High-Efficiency Genome Editing of Chlorella sp. by CRISPR/Cas9. [PDF]

Plant Biotechnol J
Cui X, Xin Y, Xiao Y, Zhang B, Gan Q, Lu Y.   +5 more
europepmc   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source