Results 281 to 290 of about 259,520 (336)

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

CRISPR/Cas9-mediated knock-in of the murine Y chromosomal genes Zfy1 and Zfy2. [PDF]

BMC Genomics
Holmlund H, Yamauchi Y, Tekayev M, Jakobs S, Robin A, Fujii W, Ward MA.   +6 more
europepmc   +1 more source

A ENGENHARIA GENÉTICA DA CRISPR/CAS9 NO GENE CCR5 COMO POSSÍVEL FONTE TERAPÊUTICA DO VÍRUS DA IMUNODEFICIÊNCIA HUMANA

Ylêdo Fernandes De Menezes Júnior, Ruth Silva Lima da Costa   +1 more
openalex   +2 more sources

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

Protocol to study the role of endogenously produced itaconate using CRISPR-Cas9 technology in THP-1 cells. [PDF]

STAR Protoc
Bourner LA, Acken KA, Long H, Chung LA, Roth KD, Dorsey FC.   +5 more
europepmc   +1 more source

The Patentability of the Crispr-Cas9 Genome Editing Tool

, 2017
Deborah Ku
openalex   +1 more source

A Review of Gene Editing Technologies in Poultry Breeding: Focus on CRISPR/Cas9

Yanlin Wang, QiQi Zhou, Jia Chen
openalex   +1 more source

Mapping the Non‐Canonical Splicing Variants: Decrypting the Hidden Genetic Architecture of Idiopathic Male Infertility

Advanced Science, EarlyView.
This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li, Yuge Chen, Dongdong Tang, Yuying Sheng, Xu Han, Hao Geng, Na Zhang, Zongliu Duan, Guanxiong Wang, Yang Gao, Rui Guo, Rong Hua, Zhiming Ding, Chuan Xu, Qunshan Shen, Zhen Yu, Bing Song, Mingrong Lv, Yuping Xu, Huan Wu, Ji Wu, Yunxia Cao, Xiaojin He   +22 more
wiley   +1 more source

CRISPR/Cas9-mediated gene editing in trophoblast cells via mechanoporation for preeclampsia insight. [PDF]

Cell Death Dis
Morshedi Rad D, Richards C, Zhand S, de Alwis N, Hannan NJ, Faiz A, McClements L, Ebrahimi Warkiani M.   +7 more
europepmc   +1 more source