Results 261 to 270 of about 217,506 (303)

Predicting the effect of CRISPR-Cas9-based epigenome editing. [PDF]

Elife
Batra SS, Cabrera A, Spence JP, Goell J, Anand SS, Hilton IB, Song YS.   +6 more
europepmc   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

CRISPR-Cas9 precision editing of kinetochore protein phosphosite codons in <i>Leishmania mexicana</i>. [PDF]

Front Cell Infect Microbiol
McNiven C, Carnielli Trindade JB, Geoghegan V, Faria JRC, Mottram JC.   +4 more
europepmc   +1 more source

Targeting STAT5A via CRISPR/Cas9 restores TKI sensitivity in resistant chronic myeloid leukemia cells. [PDF]

Med Oncol
Çelik B, Kiraz Y, Şahin Y, Tezcanlı Kaymaz B.   +3 more
europepmc   +1 more source

CRISPR/Cas9-Mediated Gene Knockout in Cereal Crops. [PDF]

Curr Protoc
Pramanik D, Wang K, Lee K.
europepmc   +1 more source

Efficient genetic perturbation of murine sensory neurons in vivo using CRISPR/Cas9. [PDF]

J Pain
García G, Shapiro JB, Campbell ZT.
europepmc   +1 more source

Changes in EGFR activity following CRISPR/Cas9-editing of the EGF binding domain. [PDF]

Sci Rep
Popović J, Hahut A, Torres GE, Vincent A, Soto-Echevarria N, Wray B, Bartom ET, Paunesku T, Goodman CR, Woloschak GE.   +9 more
europepmc   +1 more source

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CRISPR/Cas9

2023
CRISPR/Cas9 is the genome-editing technology that is most widely used around the world. Its widespread adoption is largely due to its simplicity and ease of use. Here, we introduce the construction of vectors and genome editing of the target gene in cells using the CRISPR/Cas9 system.
Izuho, Hatada, Sumiyo, Morita, Takuro, Horii   +2 more
openaire   +3 more sources

CRISPR/Cas9

2017
CRISPR/Cas9 is a novel method that has become the most widely used genome editing technology around the world. Its widespread adoption is largely due to its simplicity and easy of use. Here, we introduce the construction of vectors and genome editing of the target gene in cells expressing the CRISPR/Cas9 system.
Izuho, Hatada, Takuro, Horii
openaire   +3 more sources