Results 251 to 260 of about 243,751 (303)

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

Protocol to establish endogenous knockins in Jurkat T-ALL cells using CRISPR-Cas9-mediated homology-directed repair. [PDF]

STAR Protoc
Costa JR, Li Y, Ahrabi S, Li Z, Rapoz-D'Silva T, Krulik ME, Hyseni S, Morrow G, Guo Y, Look AT, Mansour MR.   +10 more
europepmc   +1 more source

CHST1 Drives Immunotherapy Resistance in Triple‐Negative Breast Cancer by Orchestrating an Immunosuppressive Microenvironment via the NKRF–CCL20–Macrophage Axis

Advanced Science, EarlyView.
Proposed model of CHST1‐associated immune remodeling in triple‐negative breast cancer. In CHST1‐low tumors, greater nuclear accumulation of NKRF is associated with repression of an NF‐κB‐related CCL20 transcriptional program and an immune‐inflamed microenvironment.
Shu‐Hao Jiang, Xiao‐Han Ying, Ruo‐Qing Wang, Qun Zhang, Li Chen, Zhi‐Ming Shao, Jun‐Jie Li   +6 more
wiley   +1 more source

Establishment of an Efficient CRISPR-Cas9-Mediated Gene Disruption System in the Lichen-Forming Fungus <i>Umbilicaria muhlenbergii</i>. [PDF]

J Fungi (Basel)
Wang Z, Wang N, Zhang H, Qian B, Wang D, Wang Y.   +5 more
europepmc   +1 more source

abCRISPR: deep learning-based design of abasic gRNA sequences for specific CRISPR-Cas9 genome editing. [PDF]

Bioinformatics
Kim GD, Gu D, Park M, Chi SW.
europepmc   +1 more source

Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells. [PDF]

Proc Natl Acad Sci U S A
Sabol AL, Mengiste AA, Singh P, Sreekanth V, Hendel SJ, Tran MTN, Barybin AM, Chaudhary S, Harris RM, Liivak KE, Severance ZC, Locicero CM, Kailass K, Lee C, Xu LQ, Butty VL, Choudhary A, Shoulders MD.   +17 more
europepmc   +1 more source

A method for CRISPR/Cas9-induced genetic barcoding and lineage tracing in sheep. [PDF]

Sci Rep
Hao D, Xu X, Li P, Liu Y, Liu G, Deng S.
europepmc   +1 more source

CRISPR/Cas9-Based Genome Editing: Understanding Differences in DNA Repair Pathways, Profiles, and Outcomes. [PDF]

Int J Mol Sci
Effah SN, Barrera SC, Urturi Ortiz N, Dampier W, Nonnemacher MR, Wigdahl B.   +5 more
europepmc   +1 more source

MMP9 Knockout by CRISPR-Cas9 Reduces Bladder Cancer Malignancy But Does Not Synergize With BCG and Anti-PD-L1 in an Orthotopic Mouse Model. [PDF]

IUBMB Life
Camargo JA, Lee MC, Souza MM, Silva LPD, Boas GCV, Silva KSD, Mioshi CM, Pimenta RCA, Candido P, Silva IAD, Trarbach EB, Leite KRM, Nahas WC, Reis STD.   +13 more
europepmc   +1 more source