Results 281 to 290 of about 248,807 (309)
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Catching CRISPR-Cas9 in Action
Journal of Chemical Theory and ComputationCRISPR-Cas9 has revolutionized genome editing, yet its structural dynamics and functional properties remain incompletely understood, partly due to limited atomic-level characterization of its active conformation with a full R-loop. Capitalizing on recent advances in Cas9 structural determination, we constructed a catalytic-state Cas9 model bound to a ...
Yingjie Chen +5 more
openaire +2 more sources
Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells
Cell, 2023Connor A Tsuchida +2 more
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A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression
Cell, 2021Erika Smith +2 more
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Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation
Nature Reviews Molecular Cell Biology, 2015Antonia A Dominguez +2 more
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Applying CRISPR–Cas9 tools to identify and characterize transcriptional enhancers
Nature Reviews Molecular Cell Biology, 2016Rui Lopes, Gozde Korkmaz, Reuven Agami
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High-throughput functional genomics using CRISPR–Cas9
Nature Reviews Genetics, 2015Ophir Shalem +2 more
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Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases
Nature Reviews Genetics, 2016Shengdar Q Tsai, J Keith Joung
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