Results 291 to 300 of about 259,520 (336)

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Loss of ELF2 drives topotecan resistance in retinoblastoma revealed by genome-wide CRISPR-Cas9 screening. [PDF]

Cell Death Dis
Jiang J, Jiang Z, Luo Q, Chen X, Zhuang J, Chen J, Mu Q, Qiu J, Li Y, Chen S, Zhang P, Yu K, Chen S, Liu GS, Zhuang J.   +14 more
europepmc   +1 more source

Genomic editing in Burkholderia multivorans by CRISPR/Cas9

Mirela R. Ferreira, Vasco Queiroga, Leonilde M. Moreira   +2 more
openalex   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Thiol release improvement in Saccharomyces cerevisiae oenological strains by CRISPR/Cas9-based IRC7 molecular cisgenesis. [PDF]

J Biol Eng
Granuzzo S, Bosaro M, Antoniali P, Lopreiato R.   +3 more
europepmc   +1 more source

Natural Negative Feedback Loops Confer Indica‐Japonica Differentiation for Grain Size Homeostasis in Rice

Advanced Science, EarlyView.
This study reveals the genetic and molecular mechanisms controlling grain size homeostasis through fine‐tuning OsGRX8 self‐expression by two natural negative feedback loops functioning in redox‐dependent or ‐independent manners and identifies two self‐regulatory haplotypes (SRHs) for the subspecies differentiation in rice.
Xingxing Li, Meng‐en Wu, Ziqi Qiao, Junkui Huang, Juncheng Zhang, Yang Ding, Junqing Zhu, Jingyue Xu, Yuxin Huang, Wei Li, Xiaomin Su, Yue Ding, Jianwei Zhang, Yibo Li   +13 more
wiley   +1 more source

CRISPR/Cas9 and iPSC-Based Therapeutic Approaches in Alzheimer's Disease. [PDF]

Antioxidants (Basel)
Raffaele I, Cipriano GL, Anchesi I, Oddo S, Silvestro S.   +4 more
europepmc   +1 more source

Discovering CRISPR/Cas9

, 2016
Prieto Pascual, Cristina, Universitat Autònoma de Barcelona. Facultat de Biociències   +1 more
openaire   +1 more source

Heat shock-optimized CRISPR/Cas9 system for visible clonal analysis and mutant generation in Drosophila. [PDF]

G3 (Bethesda)
Lin Y, Ye X, Zeng L, Luo Y, Feng Y, Zhang Y.   +5 more
europepmc   +1 more source