Results 201 to 210 of about 207,049 (372)

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

Cell, 2013
Baohui Chen, Luke A. Gilbert, Beth A. Cimini, J. Schnitzbauer, Wei Zhang, Gene-Wei Li, Jason Park, E. Blackburn, J. Weissman, Lei S. Qi, B. Huang   +10 more
semanticscholar   +1 more source

CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human

Advanced Science, EarlyView.
This study identifies CD168 as a conserved surface marker for proliferating β‐cells in mouse, human islets, and pancreatic islet tumors. CD168⁺ cells show high proliferation and low insulin expression. CD168+ cells form mostly uni‐β lineage clones, and some of the clones are multi‐lineage.
Shubo Yuan, Jiafu Li, Min Shao, Haili Bao, Ajun Geng, Jialin Yang, Yu Tao, Xinyi Chen, Tianxiong Xiao, Chunye Liu, Zhiyao Xie, Wenqian Song, Qing Cissy Yu, Hongxing Fu, Xu Han, Taochen He, Wenquan Wang, Jianfeng Chen, Sheng Yan, Shaohua Song, Liang Liu, Yi Arial Zeng   +21 more
wiley   +1 more source

Crop genes modified using CRISPR/Cas system

, 2017
Anna M. Korotkova, Sophia V. Gerasimova, V. K. Shumny, Е. К. Хлесткина   +3 more
openalex   +2 more sources

Inhibition of NHEJ repair by type II-A CRISPR-Cas systems in bacteria [PDF]

, 2017
Aude Bernheim, Alicia Calvo‐Villamañán, Clovis Basier, Lun Cui, Eduardo P. C. Rocha, Marie Touchon, David Bikard   +6 more
openalex   +1 more source

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source

On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires [PDF]

, 2017
Sukrit Silas, Kira S. Makarova, Sergey Shmakov, David Páez-Espino, Georg Mohr, Yi Liu, Michelle Davison, Simon Roux, Siddharth R. Krishnamurthy, Becky Xu Hua Fu, Loren L Hansen, David Wang, Matthew B. Sullivan, Andrew Millard, Martha R. J. Clokie, Devaki Bhaya, Alan M. Lambowitz, Nikos C. Kyrpides, Eugene V. Koonin, Andrew Fire   +19 more
openalex   +1 more source

RNA-Dependent RNA Targeting by CRISPR-Cas Systems: Characterizations and Applications [PDF]

, 2023
Natalia M. Gunitseva, M.A. Evteeva, Anna S. Borisova, М. В. Патрушев, Fedor V. Subach   +4 more
openalex   +1 more source

Approach for in vivo delivery of CRISPR/Cas system: a recent update and future prospect

Cellular and Molecular Life Sciences, 2021
Y. Chuang, A. Phipps, Fan-Li Lin, V. Hecht, A. Hewitt, Peng‐Yuan Wang, Guei-Sheung Liu   +6 more
semanticscholar   +1 more source

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

Advanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine

Frontiers in Genome Editing
CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR-associated proteins) has undergone marked advancements since its discovery as an adaptive immune system in bacteria and archaea, emerged as a potent gene-editing tool after the ...
Sarkar Sardar Azeez, Rahin Shareef Hamad, Bahra Kakamin Hamad, Mudhir Sabir Shekha, Mudhir Sabir Shekha, Peter Bergsten   +5 more
doaj   +1 more source