Results 181 to 190 of about 18,275,652 (330)

Genome Plasticity in Clinical Escherichia coli: Comparative Insights into Pathogenicity Islands, Prophages, and CRISPR–Cas Systems

Farah Khalid, Ali Haider Alsakini, Munim Radwan Ali   +2 more
openalex   +2 more sources

Insights into spacer acquisition of the type V-A CRISPR-Cas system of Francisella novicida U112. [PDF]

Nucleic Acids Res
Hille F, Wang C, Finstermeier K, Beerens D, Schmidt K, Skibbe M, Charpentier E.   +6 more
europepmc   +1 more source

ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites

Advanced Science, EarlyView.
ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng, Peiyuan Chai, Xiayuhe Pei, Yiwen Chen, Xiaoshuai Huang, Bei Liu, Yiqian Wu, Junlin Teng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Mismatch type impacts interference and priming activities in the type I-E CRISPR-Cas system. [PDF]

J Biol Chem
Phan PT, Ozturk M, Dougherty EM, Ravishankar J, Xue C, Sashital DG.   +5 more
europepmc   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

CRISPR–Cas systems for plant virus management: detection, surveillance, and host resistance [PDF]

Surender Kumar, Rahul Mohan Singh, Kiran R. Gadhave   +2 more
openalex   +1 more source

Structural and functional insights into the adenosine deaminase of the type III-B CRISPR-Cas system. [PDF]

Nucleic Acids Res
Li Z, Kong J, Wu W, Duan Y, Zhu Z, Hua C, Yan P, Cao C, Cao X, Xiao Y, Lu M, Chen M.   +11 more
europepmc   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Phage susceptibility to a minimal, modular synthetic CRISPR-Cas system in Pseudomonas aeruginosa is nutrient dependent. [PDF]

Philos Trans R Soc Lond B Biol Sci
Elliott JFK, Cozens K, Cai Y, Waugh G, Watson BN, Westra E, Taylor TB.   +6 more
europepmc   +2 more sources

CRISPR/CAS Technology: A Promising Tool For The Treatment Of Central Nervous System Disorders

Madhurima Tiwari1, Shifa Ahmad2, Poonam Tripathi3, Deepika Delsa Dean*
openalex   +2 more sources