Results 201 to 210 of about 18,275,652 (330)

Enhanced editing of <i>Bifidobacterium lactis</i> using the endogenous Type I-G CRISPR-Cas system. [PDF]

Appl Environ Microbiol
Raftopoulou O, Malmstrom K, Pan M, Barrangou R.   +3 more
europepmc   +1 more source

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source

Recent applications, future perspectives, and limitations of the CRISPR-Cas system. [PDF]

Mol Ther Nucleic Acids
Park SJ, Lee GE, Cho SM, Choi EH.
europepmc   +1 more source

Asymmetric Evolution of Antennal Cell Types Underlies a Derived Ammonia‐Sensing Logic for Ecological Adaptation in Bactrocera dorsalis

Advanced Science, EarlyView.
Comparative antennal single‐nucleus transcriptomics reveals cell‐type‐dependent transcriptomic divergence in Bactrocera dorsalis, with similar structural cells but divergent sensory neurons. This neuronal diversification is associated with a distinct ammonia‐sensing pathway, linking female attraction to bird‐dropping‐associated cues with nutritional ...
Wei Liu, Shuai Zhang, Jie Zhang, Zhen Tian, Yuanbo Xue, Ling Yang, Jun Xu, Guirong Wang   +7 more
wiley   +1 more source

CRISPR-Cas, expérimentation préclinique et 3R's / Towards a new, glyco-humanized rabbit line

Les applications dérivant de la technologie CRISPR-Cas (ciseaux moléculaires permettant de modifier des morceaux d’ADN n’importe où dans le génome) sont occupées à révolutionner la recherche fondamentale, appliquée, clinique et industrielle. Entre essais
Desmecht, Daniel, Ectors, Fabien, M'Boumba, Jessy, Bouvier, Justine, Martin, Ludivine   +4 more
core   +1 more source

Research progress of base editing and prime editing tools based on the CRISPR/Cas system. [PDF]

Mol Ther Nucleic Acids
Gao H, Gao S, Kan G, Valentovich LN, An Y.   +4 more
europepmc   +1 more source

Convergence of Plasmid‐Mediated tmexCD‐toprJ With Critical Resistance Genes Fuels Spread of Multidrug Resistant Bacteria

Advanced Science, EarlyView.
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song, Meng Wang, Xingyu Wu, Meng Cai, Bowen Li, Qi Wang, Xiaodong Guan, Qi Ding, Ruobing Wang, Hui Wang   +9 more
wiley   +1 more source

Association of the existence of CRISPR-Cas system and antimicrobial resistance in multi-drug resistant Klebsiella pneumoniae in Egypt. [PDF]

Sci Rep
El Menofy NG, Payoumi AN, Eissa MA, El-Sharif A.   +3 more
europepmc   +1 more source

Herbivory‐Induced Stomatal Opening Triggers the Dispersal of an Invasive Insect Herbivore

Advanced Science, EarlyView.
The invasive leafminer Phthorimaea absoluta uniquely manipulates plant defenses by inducing stomatal opening in tomato. This response, mediated by the stomatal regulator IQM1, enhances the release of the repellent volatile benzaldehyde. This volatile triggers the dispersal of adult moths, facilitates colonization of new hosts, and leads to rapid ...
Limin Chen, Xiaowei Li, Yaru Wang, Farman Ullah, Shuxing Zhou, Lemeng Dong, Weizhong He, Harro J. Bouwmeester, Youming Hou, Ian T. Baldwin, Yaobin Lu   +10 more
wiley   +1 more source

Recruitment of Cas3 enables DNA cleavage by the type I-A CRISPR-Cas system of Saccharolobus islandicus

Suping Jiang, Xuhui Tian, Fang Wang, Wenyuan Han, Qunxin She, Xu Feng   +5 more
openalex   +1 more source