Results 81 to 90 of about 207,049 (372)

BATCH-GE : batch analysis of next-generation sequencing data for genome editing assessment [PDF]

, 2016
Targeted mutagenesis by the CRISPR/Cas9 system is currently revolutionizing genetics. The ease of this technique has enabled genome engineering in-vitro and in a range of model organisms and has pushed experimental dimensions to unprecedented proportions.
Boel, Annekatrien, Callewaert, Bert, Coucke, Paul, De Paepe, Anne, De Rocker, Nina, Menten, Björn, Steyaert, Wouter, Willaert, Andy   +7 more
core   +2 more sources

Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools. [PDF]

, 2020
Appropriate empirical-based evidence and detailed theoretical considerations should be used for evolutionary explanations of phenotypic variation observed in the field of human population genetics (especially Indigenous populations). Investigators within
Fox, Keolu, Komor, Alexis C, Rallapalli, Kartik Lakshmi   +2 more
core   +2 more sources

Features of CRISPR-Cas Regulation Key to Highly Efficient and Temporally-Specific crRNA Production

Frontiers in Microbiology, 2017
Bacterial immune systems, such as CRISPR-Cas or restriction-modification (R-M) systems, affect bacterial pathogenicity and antibiotic resistance by modulating horizontal gene flow.
Andjela Rodic, Andjela Rodic, Bojana Blagojevic, Magdalena Djordjevic, Konstantin Severinov, Konstantin Severinov, Marko Djordjevic   +6 more
doaj   +1 more source

A genomic sequence of the type II-A clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated system in Mycoplasma salivarium strain ATCC 29803

Journal of Oral Microbiology, 2022
Introduction Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated systems are RNA-mediated adaptive immune systems that actagainst invading genetic elements such as phages or plasmids.
Harumi Mizuki, Yu Shimoyama, Taichi Ishikawa, Minoru Sasaki   +3 more
doaj   +1 more source

Coexistence of blaKPC-IncFII plasmids and type I-E* CRISPR-Cas systems in ST15 Klebsiella pneumoniae

Frontiers in Microbiology, 2023
The CRISPR-Cas system in Klebsiella pneumoniae can prevent the entry of blaKPC-IncF plasmids. However, some clinical isolates bear the KPC-2 plasmids despite carrying the CRISPR-Cas system.
Yiyi Hu, Yiyi Hu, Jianping Jiang, Jianping Jiang, Dongliang Wang, Qinglan Guo, Qinglan Guo, Minggui Wang, Minggui Wang   +8 more
doaj   +1 more source

Applications of CRISPR–Cas systems in neuroscience [PDF]

, 2016
Genome-editing tools, and in particular those based on CRISPR-Cas (clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated protein) systems, are accelerating the pace of biological research and enabling targeted genetic ...
A Bolotin, A Fire, A Geling, A Plessis, A Xiao, A Zeisel, AJ Wood, AM Geurts, AN Shah, AW Chan, AY Cheung, B Chen, B Pardo, B Zetsche, B Zetsche, C Burger, C Pak, C Straub, D Kim, D Maddalo, D St Johnston, DB Cox, DC van Gent, E Deltcheva, E Sasaki, EA Brenowitz, EB Lewis, EE Patton, EM Jorgensen, F Liang, F Soldner, F Zhang, FA Ran, FA Ran, FD Urnov, Feng Zhang, G Gasiunas, G Murlidharan, GP Flowers, H Akil, H Liu, H Wang, H Xia, HB Kordasiewicz, I Harel, I Jeon, IB Hilton, ID Carbery, IE Clark, J Boch, J Fishman-Lobell, J Fishman-Lobell, J Morton, J Peters, JA Harris, JA Zuris, JC Belmonte, JC Miller, JD Hommel, JD Sander, JD Sander, JD Sweatt, JE Garneau, JL Bessereau, JM Taymans, KJ Beumer, KR Thomas, KS Makarova, KY Kim, L Cong, L Cooley, L Swiech, LA Gilbert, LE Dow, LE Jao, LR Polstein, LS Qi, M Bibikova, M Bibikova, M Christian, M Garriga-Canut, M Jinek, M Maresca, M Zuckermann, Matthias Heidenreich, MC Marchetto, MJ Moscou, N Gaiano, N Rudin, N Wittenburg, NA Kearns, P Essletzbichler, P Mali, P Mali, P Qiu, P Rouet, P Rouet, PD Hsu, R Barrangou, RA Smith, RB Blasco, RD Johnson, RJ Platt, RR Beerli, S Incontro, S Konermann, S Konermann, S Oddo, SD Ryan, SH Yang, SM Elbashir, SQ Tsai, T Katsuyama, T Yagi, TO Auer, VM Bedell, Y Doyon, Y Fu, Y Niu, YG Kim, Z Shen   +120 more
core   +1 more source

Production and analysis of synthetic Cascade variants [PDF]

, 2020
CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR assoziiert) ist ein adaptives Immunsystem in Archaeen und Bakterien, das fremdes genetisches Material mit Hilfe von Ribonukleoprotein-Komplexen erkennt und zerstört.
Gleditzsch, Daniel
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Bioinformational analysis of Yersinia pseudotuberculosis IP32953 CRISPR/cas system

Acta Biomedica Scientifica, 2016
The results of this study include Yersinia pseudotuberculosis CRISPR/Cas system structure analysis. CRISPR/Cas system is a specific adaptive protection against heterogeneous genetic elements.
N. P. Peretolchina, Y. P. Dzhioev, A. Y. Borisenko, E. A. Voskresenskaya, A. I. Paramonov, L. A. Stepanenko, O. V. Kolbaseeva, V. I. Zlobin   +7 more
doaj   +1 more source

Protospacer-Adjacent Motif Specificity during Clostridioides difficile Type I-B CRISPR-Cas Interference and Adaptation

mBio, 2021
CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated) systems provide prokaryotes with efficient protection against foreign nucleic acid invaders. We have recently demonstrated the defensive interference function of a
Anna Maikova, Pierre Boudry, Anna Shiriaeva, Aleksandra Vasileva, Anaïs Boutserin, Sofia Medvedeva, Ekaterina Semenova, Konstantin Severinov, Olga Soutourina   +8 more
doaj   +1 more source