Results 11 to 20 of about 58,663 (324)
Applications of CRISPR–Cas systems in neuroscience [PDF]
Nature Reviews Neuroscience, 2015 Genome-editing tools, and in particular those based on CRISPR-Cas (clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated protein) systems, are accelerating the pace of biological research and enabling targeted genetic interrogation in almost any organism and cell type. These tools have opened the door to the development of
Matthias Heidenreich, Feng Zhang
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Occurrence and Diversity of CRISPR-Cas Systems in the Genus Bifidobacterium. [PDF]
PLoS ONE, 2015 CRISPR-Cas systems constitute adaptive immune systems for antiviral defense in bacteria. We investigated the occurrence and diversity of CRISPR-Cas systems in 48 Bifidobacterium genomes to gain insights into the diversity and co-evolution of CRISPR-Cas ...
Alexandra E Briner +9 more
doaj +3 more sources
CRISPR-Cas Systems in Prokaryotes [PDF]
Polish Journal of Microbiology, 2015 Prokaryotic organisms possess numerous strategies that enable survival in hostile conditions. Among others, these conditions include the invasion of foreign nucleic acids such as bacteriophages and plasmids. The clustered regularly interspaced palindromic repeats-CRISPR-associated proteins (CRISPR-Cas) system provides the majority of bacteria and ...
Burmistrz, Michał, Pyrć, Krzysztof
openaire +6 more sources
Viral Diversity Threshold for Adaptive Immunity in Prokaryotes [PDF]
mBio, 2012 Bacteria and archaea face continual onslaughts of rapidly diversifying viruses and plasmids. Many prokaryotes maintain adaptive immune systems known as clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated genes (Cas ...
Ariel D. Weinberger +4 more
doaj +3 more sources
Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems [PDF]
Biology Direct, 2011 Background The CRISPR-Cas adaptive immunity systems that are present in most Archaea and many Bacteria function by incorporating fragments of alien genomes into specific genomic loci, transcribing the inserts and using the transcripts as guide RNAs to ...
Wolf Yuri I +3 more
doaj +5 more sources
Application of CRISPR Cas Systems for Biosensing. [PDF]
Biosensors (Basel), 2023 The essential properties of a biosensor are its sensitivity and selectivity to detect, monitor and quantify the biomarker(s) for the interests of medicine [...]
Liu CC, Dai Y.
europepmc +4 more sources
Physical model of the immune response of bacteria against bacteriophage through the adaptive CRISPR-Cas immune system [PDF]
, 2013 Bacteria and archaea have evolved an adaptive, heritable immune system that recognizes and protects against viruses or plasmids. This system, known as the CRISPR-Cas system, allows the host to recognize and incorporate short foreign DNA or RNA sequences,
Pu Han +3 more
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CRISPR-Cas systems and applications for crop bioengineering. [PDF]
Front Bioeng BiotechnolCRISPR–Cas technologies contribute to enhancing our understanding of plant gene functions, and to the precise breeding of crop traits. Here, we review the latest progress in plant genome editing, focusing on emerging CRISPR–Cas systems, DNA-free delivery methods, and advanced editing approaches.
Uranga M +3 more
europepmc +6 more sources
Adaptation in CRISPR-Cas Systems [PDF]
Molecular Cell, 2016 Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system in prokaryotes. The system preserves memories of prior infections by integrating short segments of foreign DNA, termed spacers, into the CRISPR array in a process termed adaptation.
Samuel H. Sternberg +3 more
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Investigating the Genomic Background of CRISPR-Cas Genomes for CRISPR-Based Antimicrobials
Evolutionary Bioinformatics, 2022 CRISPR-Cas systems are an adaptive immunity that protects prokaryotes against foreign genetic elements. Genetic templates acquired during past infection events enable DNA-interacting enzymes to recognize foreign DNA for destruction.
Hyunjin Shim
doaj +1 more source