Results 11 to 20 of about 38,793 (285)

Occurrence and Diversity of CRISPR-Cas Systems in the Genus Bifidobacterium. [PDF]

PLoS ONE, 2015
CRISPR-Cas systems constitute adaptive immune systems for antiviral defense in bacteria. We investigated the occurrence and diversity of CRISPR-Cas systems in 48 Bifidobacterium genomes to gain insights into the diversity and co-evolution of CRISPR-Cas ...
Alexandra E Briner, Gabriele Andrea Lugli, Christian Milani, Sabrina Duranti, Francesca Turroni, Miguel Gueimonde, Abelardo Margolles, Douwe van Sinderen, Marco Ventura, Rodolphe Barrangou   +9 more
doaj   +3 more sources

Functional Features and Current Applications of the RNA‐Targeting Type VI CRISPR‐Cas Systems

Advanced Science, 2021
CRISPR‐Cas systems are a form of prokaryotic adaptive immunity that employs RNA‐guided endonucleases (Cas effectors) to cleave foreign genetic elements.
Vanja Perčulija, Jinying Lin, Bo Zhang, Songying Ouyang   +3 more
doaj   +2 more sources

Insight into the natural regulatory mechanisms and clinical applications of the CRISPR-Cas system

Heliyon
CRISPR-Cas, the adaptive immune system exclusive to prokaryotes, confers resistance against foreign mobile genetic elements. The CRISPR-Cas system is now being exploited by scientists in a diverse range of genome editing applications.
Hui Cheng, Haoyue Deng, Dongdao Ma, Mengyuan Gao, Zhihan Zhou, Heng Li, Shejuan Liu, Tieshan Teng   +7 more
doaj   +2 more sources

CRISPR-Cas systems feature and targeting phages diversity in Lacticaseibacillus rhamnosus strains

Frontiers in Microbiology, 2023
One of the most important adaptive immune systems in bacteria against phages is clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (CAS) genes.
Bahman Panahi, Behnaz Dehganzad, Yousef Nami   +2 more
doaj   +1 more source

CRISPR-Cas Systems in Prokaryotes [PDF]

Polish Journal of Microbiology, 2015
Prokaryotic organisms possess numerous strategies that enable survival in hostile conditions. Among others, these conditions include the invasion of foreign nucleic acids such as bacteriophages and plasmids. The clustered regularly interspaced palindromic repeats-CRISPR-associated proteins (CRISPR-Cas) system provides the majority of bacteria and ...
Burmistrz, Michał, Pyrć, Krzysztof
openaire   +3 more sources

Das CRISPR/Cas‐System [PDF]

Biologie in unserer Zeit, 2018
Pflanzen können von einer Vielzahl an Pathogenen befallen werden, die schwerwiegende Krankheiten auslösen und besonders bei Nutzpflanzen zu starken Ernteverlusten beitragen. CRISPR/Cas‐Systeme verändern die Angriffsstellen dieser Pathogene hochpräzise, sodass ein Befall nicht mehr stattfinden kann – eine Entwicklung, die als Revolution in der ...
Patrick Schindele, Felix Wolter, Holger Puchta   +2 more
openaire   +2 more sources

Adaptation in CRISPR-Cas Systems [PDF]

Molecular Cell, 2016
Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system in prokaryotes. The system preserves memories of prior infections by integrating short segments of foreign DNA, termed spacers, into the CRISPR array in a process termed adaptation.
Samuel H. Sternberg, Hagen Richter, Emmanuelle Charpentier, Udi Qimron   +3 more
openaire   +4 more sources

CRISPR-Cas Systems in Streptococci [PDF]

Current Issues in Molecular Biology, 2019
Streptococci are one of the most important and common constituents of the host's microbiota and can colonize and live in the upper respiratory and urogenital tract of humans and animals. The CRISPR-Cas systems (i.e., clustered regularly interspaced short palindromic repeat, with CRISPR-associated proteins) found in bacteria and archaea provide sequence-
Tao, Gong, Miao, Lu, Xuedong, Zhou, Anqi, Zhang, Boyu, Tang, Jiamin, Chen, Meiling, Jing, Yuqing, Li   +7 more
openaire   +2 more sources

New CRISPR-Cas systems discovered [PDF]

Cell Research, 2017
In bacteria and archaea, CRISPR-Cas adaptive immune systems utilize RNA-guided endonucleases to defend against invasion by foreign nucleic acids of bacteriophage, virus and plasmid origin. In a recent paper published in Nature, Burstein et al. identified the first Cas9 protein in uncultivated archaea and two novel CRISPR-CasX and CRISPR-CasY systems in
Hui, Yang, Dinshaw J, Patel
openaire   +2 more sources

Nonviral Delivery of CRISPR/Cas Systems in mRNA Format

Advanced NanoBiomed Research, 2022
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated (Cas) genome editing system provides a powerful toolbox for genetic engineering.
Zhen Liu, Zhenghua Li, Bin Li
doaj   +1 more source