Results 201 to 210 of about 58,663 (324)

PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti‐TIGIT Therapy in Microsatellite‐Stable Colorectal Cancer

Advanced Science, EarlyView.
Microsatellite‐stable (MSS) colorectal cancer (CRC) resists immunotherapy. PRMT5 inhibition enhances CPT‐11 sensitivity, inducing a PMS2‐deficient‐like state and cytosolic dsDNA release, which activates the cGAS‐STING pathway to promote anti‐tumor immunity. However, this combination therapy upregulates TIGIT expression on CD8+ T cells, and the addition
Jiang Zhu, Shenao Fu, Xi Zou, Hanjiang Zeng, Guangzu Cui, Yinghui Peng, Diya Tang, Fan Zhang, Hong Shen, Shan Zeng, Ying Han   +10 more
wiley   +1 more source

Faculty Opinions recommendation of Multiplex genome engineering using CRISPR/Cas systems.

, 2013
Michael H. Gelb
openalex   +2 more sources

Gastrula‐Premarked Posterior Enhancer Primes Posterior Tissue Development Through Cross‐Talk with TGF‐β Signaling Pathway

Advanced Science, EarlyView.
A gastrula‐premarked enhancer within the first intron of Cdx2 governs posterior embryonic development via both regulating Cdx2 expression in cis and coordinating TGF‐β signaling in trans to ensure proper posterior body development. Functional rescue in gastruloids reveals a Cdx2‐independent pathway, highlighting p‐Enh‐eRNA as key epigenetic ...
Yingying Chen, Fengxiang Tan, Qing Fang, Lin Zhang, Jiaoyang Liao, Penglei Shen, Yun Qian, Mingzhu Wen, Rui Song, Yonggao Fu, He Jax Xu, Ran Wang, Cheng Li, Zhen Shao, Jinsong Li, Naihe Jing, Xianfa Yang   +16 more
wiley   +1 more source

Priming in a permissive type I-C CRISPR–Cas system reveals distinct dynamics of spacer acquisition and loss [PDF]

, 2017
Chitong Rao, Denny Chin, Alexander W. Ensminger   +2 more
openalex   +1 more source

CRISPR-Cas Systems: A Functional Perspective and Innovations. [PDF]

Int J Mol Sci
Navarro C, Díaz MP, Duran P, Castro A, Díaz A, Cano C, Carbonell-Zabaleta AK, Solano-Jimenez DS, Rivera-Porras D, Contreras-Velásquez JC, Bermúdez V.   +10 more
europepmc   +1 more source

Current trends of clinical trials involving CRISPR/Cas systems. [PDF]

Front Med (Lausanne), 2023
Zhang S, Wang Y, Mao D, Wang Y, Zhang H, Pan Y, Wang Y, Teng S, Huang P.   +8 more
europepmc   +1 more source

Gut Metabolite Indole‐3‐Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging‐Related Myocardial Fibrosis

Advanced Science, EarlyView.
IPA is an intestinal tryptophan metabolite whose effects decline with decreased heart function. Supplementing IPA can alleviate the aging‐related myocardial fibrosis through PPT1. PPT1 is a key protein localized to lysosomes, and IPA can restore macrophage autophagy function by regulating PPT1 expresssions, thereby reducing aging‐related myocardial ...
Jing Lu, Hongyan Wang, Haiyu Zhang, Jiahao Li, Hanqi Li, Qiuyu Chen, Dongyu Han, Jialiang Liu, Lin Lv, Jie Xiong, Keying Yuan, Xianpeng Wei, Siqi Sheng, Fukai Liu, Yuanqi Shi, Zengxiang Dong, Yue Li   +16 more
wiley   +1 more source

MISSA 2.0: an updated synthetic biology toolbox for assembly of orthogonal CRISPR/Cas systems [PDF]

, 2017
Haiyan Zhang, Xinghui Wang, Dong Li, Zhiping Wang, Bing Liu, Jie Lv, Xing Hui-li, Chunyan Han, Xuechen Wang, Qijun Chen   +9 more
openalex   +1 more source

The Use of CRISPR-Cas Systems for Viral Detection: A Bibliometric Analysis and Systematic Review. [PDF]

Biosensors (Basel)
Jeddoub O, Touil N, Nyabi O, El Fahime E, Ennibi K, Gala JL, Benjouad A, Belayachi L.   +7 more
europepmc   +1 more source

Comparative Analysis of CRISPR-Cas Systems in Pseudomonas Genomes. [PDF]

Genes (Basel), 2023
Parra-Sánchez Á, Antequera-Zambrano L, Martínez-Navarrete G, Zorrilla-Muñoz V, Paz JL, Alvarado YJ, González-Paz L, Fernández E.   +7 more
europepmc   +1 more source