Results 21 to 30 of about 64,011 (196)

Comparison of CRISPR–Cas Immune Systems in Healthcare-Related Pathogens

Frontiers in Microbiology, 2021
The ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) and Clostridium difficile have been identified as the leading global cause of multidrug ...
Kate Mortensen, Tony J. Lam, Yuzhen Ye
doaj   +1 more source

Phylogenetic Distribution of CRISPR-Cas Systems in Staphylococcus lugdunensis

Microbiology Spectrum, 2021
Clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated (Cas) genes (CRISPR-Cas) are present in many bacterial genomes with functions beyond adaptive immunity.
Cheng-Yen Kao, Jang-Jih Lu, Lee-Chung Lin, Hsiao-Chi Lin, Shih-Cheng Chang   +4 more
doaj   +1 more source

CRISPR-Cas systems in enterococci. [PDF]

Braz J Microbiol
Enterococci are members of the microbiota of humans and other animals. They can also be found in the environment, associated with food, healthcare infections, and hospital settings. Due to their wide distribution, they are inserted in the One Health context.
Cabral AS, Lacerda FF, Leite VLM, de Miranda FM, da Silva AB, Dos Santos BA, Lima JLDC, Teixeira LM, Neves FPG.   +8 more
europepmc   +3 more sources

Das CRISPR/Cas‐System [PDF]

Biologie in unserer Zeit, 2018
Pflanzen können von einer Vielzahl an Pathogenen befallen werden, die schwerwiegende Krankheiten auslösen und besonders bei Nutzpflanzen zu starken Ernteverlusten beitragen. CRISPR/Cas‐Systeme verändern die Angriffsstellen dieser Pathogene hochpräzise, sodass ein Befall nicht mehr stattfinden kann – eine Entwicklung, die als Revolution in der ...
Patrick Schindele, Felix Wolter, Holger Puchta   +2 more
openaire   +2 more sources

Adaptation in CRISPR-Cas Systems [PDF]

Molecular Cell, 2016
Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system in prokaryotes. The system preserves memories of prior infections by integrating short segments of foreign DNA, termed spacers, into the CRISPR array in a process termed adaptation.
Samuel H. Sternberg, Hagen Richter, Emmanuelle Charpentier, Udi Qimron   +3 more
openaire   +4 more sources

CRISPR-Cas Systems in Streptococci [PDF]

Current Issues in Molecular Biology, 2019
Streptococci are one of the most important and common constituents of the host's microbiota and can colonize and live in the upper respiratory and urogenital tract of humans and animals. The CRISPR-Cas systems (i.e., clustered regularly interspaced short palindromic repeat, with CRISPR-associated proteins) found in bacteria and archaea provide sequence-
Tao, Gong, Miao, Lu, Xuedong, Zhou, Anqi, Zhang, Boyu, Tang, Jiamin, Chen, Meiling, Jing, Yuqing, Li   +7 more
openaire   +2 more sources

New CRISPR-Cas systems discovered [PDF]

Cell Research, 2017
In bacteria and archaea, CRISPR-Cas adaptive immune systems utilize RNA-guided endonucleases to defend against invasion by foreign nucleic acids of bacteriophage, virus and plasmid origin. In a recent paper published in Nature, Burstein et al. identified the first Cas9 protein in uncultivated archaea and two novel CRISPR-CasX and CRISPR-CasY systems in
Hui, Yang, Dinshaw J, Patel
openaire   +2 more sources

CRISPR-Cas systems in multicellular cyanobacteria [PDF]

RNA Biology, 2018
Novel CRISPR-Cas systems possess substantial potential for genome editing and manipulation of gene expression. The types and numbers of CRISPR-Cas systems vary substantially between different organisms. Some filamentous cyanobacteria harbor > 40 different putative CRISPR repeat-spacer cassettes, while the number of cas gene instances is much lower ...
Shengwei Hou, Manuel Brenes-Álvarez, Viktoria Reimann, Omer S. Alkhnbashi, Rolf Backofen, Alicia M. Muro-Pastor, Wolfgang R. Hess   +6 more
openaire   +4 more sources

CRISPR-Cas systems in Proteus mirabilis

Infection, Genetics and Evolution, 2021
The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) is a bacterial defense mechanism against bacteriophages composed of two different parts: the CRISPR array and the Cas genes. The spacer acquisition is done by the adaptation module consisting of the hallmark Cas1 Cas2 proteins, which inserts new spacers into the CRISPR array.
Mahnaz Shafaei, Fallah, Alireza, Mohebbi, Mohammad, Yasaghi, Ezzat Allah, Ghaemi   +3 more
openaire   +2 more sources

Using CRISPR-Cas systems as antimicrobials [PDF]

Current Opinion in Microbiology, 2017
Although CRISPR-Cas systems naturally evolved to provide adaptive immunity in bacteria and archaea, Cas nucleases can be co-opted to target chromosomal sequences rather than invasive genetic elements. Although genome editing is the primary outcome of self-targeting using CRISPR-based technologies in eukaryotes, self-targeting by CRISPR is typically ...
Bikard, David, Barrangou, Rodolphe
openaire   +3 more sources