Results 21 to 30 of about 291,035 (304)
Today's Biothreats – Where the Past Predictions Meet the Future
Вестник войск РХБ защиты, 2020 The catastrophic spread of COVID-19 pandemic, uncontrolled by modern medical science, regardless of whether it is artificial or not, clearly shows the limits of human mind and knowledge to resist this and other similar challenges.
J. Lakota
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Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
Nature Biotechnology, 2015 CRISPR-Cas9–based genetic screens are a powerful new tool in biology. By simply altering the sequence of the single-guide RNA (sgRNA), one can reprogram Cas9 to target different sites in the genome with relative ease, but the on-target activity and off ...
John G Doench +12 more
semanticscholar +1 more source
Desarrollo de nuevos diseños vegetales: Mejora genética vs transformación genética y edición génica
Magna Scientia UCEVA, 2021 El objetivo de esta reflexión es realizar un estudio comparativo sobre la eficacia, eficiencia técnica y costo de las tecnologías más importantes para el desarrollo de nuevos diseños vegetales, incluyendo la mejora genética, la transformación genética y ...
Pedro Martínez Gómez
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Current trends and new methods of detection of SARS-CoV-2 infection [PDF]
Cellular, Molecular and Biomedical Reports, 2022 SARS-CoV- 2 is the causative agent of the global pandemic, also known as Covid-19. This virus belongs to a group of coronaviruses and has affected more than ten million people across the globe, causing nearly half a million deaths worldwide. The pandemic
Mohammad Mohammadi +2 more
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CRISPR/Cas9 therapeutics: progress and prospects
Signal Transduction and Targeted Therapy, 2023 Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases by permanently correcting deleterious base mutations or disrupting disease-
Tianxiang Li +9 more
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Off-target effects in CRISPR/Cas9 gene editing
Frontiers in Bioengineering and Biotechnology, 2023 Gene editing stands for the methods to precisely make changes to a specific nucleic acid sequence. With the recent development of the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system, gene editing has become efficient ...
Congting Guo +3 more
semanticscholar +1 more source
The current advances of CRISPR/Cas-based systems for the detection of COVID-19
Journal of Current Biomedical Reports, 2021 The novel coronavirus disease 2019 (COVID-19) still poses a serious threat to every human on the planet nearly 1.5 years after its beginning. Unfortunately, the current diagnostic methods, although highly sensitive and specific, still suffer from many ...
Sasan Ghaffari +2 more
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Journal of Public Health and Primary Care, 2020 Our purpose is to discuss ethical concerns with disease prevention applications of CRISPR germline editing using a human rights approach. If applied towards furthering health, these tools may aid to prevent diseases, thereby improving health and reduce ...
Lance Garrett Shaver +2 more
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FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Plants, 2020 Inositol trisphosphate 5/6 kinases (ITPK) constitute a small group of enzymes participating in the sequential phosphorylation of inositol phosphate to inositol hexakisphosphate (IP6), which is a major storage form of phosphate in cereal grains.
Tomáš Vlčko, Ludmila Ohnoutková
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