Results 21 to 30 of about 315,823 (196)

Cas6 specificity and CRISPR RNA loading in a complex CRISPR-Cas system [PDF]

, 2014
This research was funded in part by Biotechnology and Biological Sciences Research Council [BB/K000314/1]. The APC was paid through RCUK OA block grant funds.CRISPR-Cas is an adaptive prokaryotic immune system, providing protection against viruses and ...
Malcolm F. White, White, Malcolm F, Shirley Graham, Sokolowski, Richard David, Graham, Shirley, Richard D. Sokolowski, White, Malcolm F.; id_orcid, Sokolowski, Richard D.   +7 more
core   +1 more source

Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity [PDF]

, 2015
EC is supported by the Alexander von Humboldt Foundation, the German Federal Ministry for Education and Research, the Helmholtz Association, the Göran Gustafsson Foundation, the Swedish Research Council, the Kempe Foundation and Umeå University.
White, Malcolm F., Charpentier, Emmanuelle, White, Malcolm F, van der Oost, John, Richter, Hagen, Oost, John, van der, Charpentier, Emmanuelle,, White, Malcolm F; id_orcid   +7 more
core   +1 more source

CRISPR decoys [PDF]

RNA Biology, 2013
CRISPR loci consist of an array of short repeats separated by spacer sequences that match the genome of viruses and plasmids that infect prokaryotes. Transcription of the CRISPR array generates small antisense RNAs that mediate immunity against these invaders.
Inbal, Maniv, Asma, Hatoum-Aslan, Luciano A, Marraffini   +2 more
openaire   +2 more sources

CRISPR-mediated targeted mRNA degradation in the archaeon Sulfolobus solfataricus [PDF]

, 2014
European SulfoSYS-project [SysMo P–N-01-09-23] and grant [9P23000 and P25369] by the Austrian Research fund (to C.S.) and by grant [BB/K000314/1] from the Biotechnology and Biological Sciences Research Council (to M.F.W.). Funding for open access charge:
Manica, A., Zebec, Z., Schleper, C., Zhang, J., White, M.F., White, M.F.; id_orcid   +5 more
core   +1 more source

A Unique B-Family DNA Polymerase Facilitating Error-Prone DNA Damage Tolerance in Crenarchaeota

Frontiers in Microbiology, 2020
Sulfolobus islandicus codes for four DNA polymerases: three are of the B-family (Dpo1, Dpo2, and Dpo3), and one is of the Y-family (Dpo4). Western analysis revealed that among the four polymerases, only Dpo2 exhibited DNA damage-inducible expression.
Xu Feng, Xiaotong Liu, Ruyi Xu, Ruiliang Zhao, Wenqian Feng, Jianglan Liao, Wenyuan Han, Qunxin She   +7 more
doaj   +1 more source

Hot and crispy : CRISPR-Cas systems in the hyperthermophile Sulfolobus solfataricus [PDF]

, 2013
The CRISPR (clustered regularly interspaced short palindromic repeats) and Cas (CRISPR-associated) genes are widely spread in bacteria and archaea, representing an intracellular defence system against invading viruses and plasmids.
Zhang, Jing, White, Malcolm F., White, Malcolm F.; id_orcid   +2 more
core   +1 more source

Immaculate Conception? Priority and Invention in the CRISPR Patent Dispute [PDF]

, 2022
The U.S. Patent Trial and Appeal Board (PTAB), in an interference proceeding decided in February 2022, con- cluded that researchers at the Broad Institute (Cambridge, MA) were the first to ‘‘conceive’’ of using single- guide RNA CRISPR-Cas9 genome ...
Sherkow, Jacob S., Jacob S. Sherkow
core   +1 more source

Today's Biothreats – Where the Past Predictions Meet the Future

Вестник войск РХБ защиты, 2020
The catastrophic spread of COVID-19 pandemic, uncontrolled by modern medical science, regardless of whether it is artificial or not, clearly shows the limits of human mind and knowledge to resist this and other similar challenges.
J. Lakota
doaj   +1 more source

Structure of the archaeal Cascade subunit Csa5 : Relating the small subunits of CRISPR effector complexes [PDF]

, 2013
This work was funded by a grant from the Biotechnology and Biological Sciences Research Council (BBSRC) (REF: BB/G011400/1) to M.F.W. and J.H.N. and a BBSRC-funded studentship to J.R.The Cascade complex for CRISPR-mediated antiviral immunity uses CRISPR ...
Naismith, Jim, White, Malcolm F, Anderson, Linzi, Liu, Huanting, Reeks, Judith Anne, Graham, Shirley, White, Malcolm F.; id_orcid, Reeks, Judith, Naismith, James H.   +8 more
core   +1 more source

CRISPR-ATAC

, 2023
CRISPR-ATAC has been developed by Yuki Kagoya's group (Keio University School of Medicine). The algorithm is implemented in Google Colaboratory to extract gRNA targets with efficient indel formation using the CRISPR/Cas9 system.
Yusuke Ito (17276582), Tetsuo Ishikawa (17276611), Yuki Kagoya (17276539)   +2 more
core   +1 more source