Results 11 to 20 of about 1,687 (191)

Structural studies on a lipoarabinogalactan of Crithidia fasciculata [PDF]

Biochemical Journal, 1996
The monosaccharide D-arabinopyranose has only been found in glycoconjugates of the trypanosomatid parasites Leishmania major, Endotrypanum schaudinni and Crithidia fasciculata. The donor molecule for the relevant arabinosyltransferases is known to be GDP-α-D-Arap in L. major and C.
Schneider, P, Treumann, A, Milne, KG, McConville, MJ, Zitzmann, N, Ferguson, MAJ   +5 more
openaire   +5 more sources

Leishmania ITS1 Is Genetically Divergent in Asymptomatic and Symptomatic Visceral Leishmaniasis: Results of a Study in Southern Iran

Journal of Tropical Medicine, 2020
It has been documented that the genotypic traits in symptomatic and asymptomatic cases of visceral leishmaniasis (VL) may be different. The current study aimed to find out and compare the genotype and intraspecies diversity of Leishmania Internal ...
Zahra Rezaei, Eqlima Azarang, Saeed Shahabi, Mostafa Omidian, Bahman Pourabbas, Bahador Sarkari   +5 more
doaj   +2 more sources

Comparative metabolism of conjugated and unconjugated pterins in Crithidia, Leishmania and African trypanosomes. [PDF]

PLoS Neglected Tropical Diseases
Mammalian cells synthesise tetrahydrobiopterin de novo, an essential cofactor for hydroxylation of aromatic amino acids, cleavage of ether lipids and the synthesis of nitric oxide.
Han B Ong, Susan Wyllie, Alan H Fairlamb
doaj   +2 more sources

Mitochondrial DNA ligase in Crithidia fasciculata. [PDF]

Proc Natl Acad Sci U S A, 2004
Kinetoplast DNA (kDNA), the form of mitochondrial DNA in trypanosomatids, consists of thousands of interlocked circular DNAs organized into a compact disk structure. A type II DNA topoisomerase, a DNA polymerase β, and a structure-specific endonuclease have been localized to antipodal sites flanking the kDNA disk along with nascent DNA ...
Sinha KM, Hines JC, Downey N, Ray DS.
europepmc   +4 more sources

European propolis is highly active against trypanosomatids including Crithidia fasciculata. [PDF]

Sci Rep, 2019
Extracts of 35 samples of European propolis were tested against wild type and resistant strains of the protozoal pathogens Trypanosoma brucei, Trypanosoma congolense and Leishmania mexicana.
Alotaibi A, Ebiloma GU, Williams R, Alenezi S, Donachie AM, Guillaume S, Igoli JO, Fearnley J, de Koning HP, Watson DG.   +9 more
europepmc   +3 more sources

A conserved trypanosomatid differentiation regulator controls substrate attachment and morphological development in Trypanosoma congolense. [PDF]

PLoS Pathogens
Trypanosomatid parasites undergo developmental regulation to adapt to the different environments encountered during their life cycle. In Trypanosoma brucei, a genome wide selectional screen previously identified a regulator of the protein family ESAG9 ...
Eleanor Silvester, Balazs Szoor, Alasdair Ivens, Georgina Awuah-Mensah, Catarina Gadelha, Bill Wickstead, Keith R Matthews   +6 more
doaj   +2 more sources

Use of Crithidia fasciculata extract for the facile enzymatic synthesis of GDP-L-[3H]Fucose. [PDF]

Glycobiology
For studies involving glycosyltransferases and nucleotide sugar transporters, radioactive nucleotide sugars are critical reagents. Of these, GDP-L-[3H]Fucose is currently commercially unavailable. Here, we present a facile approach for the preparation of
Paredes Franco JC, Güther MLS, Ferguson MAJ.   +2 more
europepmc   +3 more sources

Roles and interactions of the specialized initiation factors EIF4E2, EIF4E5, and EIF4E6 in Trypanosoma brucei: EIF4E2 maintains the abundances of S‐phase mRNAs

Molecular Microbiology, Volume 118, Issue 4, Page 457-476, October 2022., 2022
Trypanosoma brucei has six versions of the cap‐binding translation initiation factor EIF4E. We here, for bloodstream‐form trypanosomes, confirm the proteins that were previously found to be associated with each in procyclic forms, and show that EIF4E6 depletion causes growth arrest, EIF4E5 is dispensable, and cells lacking EIF4E2 grow extremely slowly.
Franziska Falk, Rafael Melo Palhares, Albina Waithaka, Christine Clayton   +3 more
wiley   +1 more source

Isolation and Antimicrobial Activities of Phytochemicals from Parinari curatellifolia (Chrysobalanaceae)

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2021, Issue 1, 2021., 2021
The widespread use of antimicrobial agents to treat infectious diseases has led to the emergence of antibiotic resistant pathogens. Plants have played a central role in combating many ailments in humans, and Parinari curatellifolia has been used for medicinal purposes. Seven extracts from P.
Phillip Mawire, Winnie Mozirandi, Matthias Heydenreich, Godloves Fru Chi, Stanley Mukanganyama, Abdelhakim Bouyahya   +5 more
wiley   +1 more source

The Growth and Nutrition of Crithidia fasciculata [PDF]

Journal of General Microbiology, 1958
The conditions for luxuriant axenic cultivation of the trypanosomid flagellate Crithidia fasciculata in chemically-defined media were determined. Improvements over the hitherto published media include higher concentrations of amino acids, folic acid (where this is the sole source of pteridine) and purines and the inclusion of threonine and Tween 80 ...
G W, KIDDER, B N, DUTTA
openaire   +2 more sources