Results 41 to 50 of about 1,687 (191)

Cell Signaling with Extracellular Thioredoxin and Thioredoxin‐Like Proteins: Insight into Their Mechanisms of Action

Oxidative Medicine and Cellular Longevity, Volume 2017, Issue 1, 2017., 2017
Thioredoxins are small thiol‐oxidoreductase enzymes that control cellular redox homeostasis. Paradoxically, human thioredoxin (TXN1) was first identified as the adult T cell leukemia‐derived factor (ADF), a secreted protein. ADF has been implicated in a wide variety of cell‐to‐cell communication systems acting as a cytokine or a chemokine.
Thierry Léveillard, Najate Aït-Ali, Sergio Di Meo   +2 more
wiley   +1 more source

Evolutionary History of Terrestrial Pathogens and Endoparasites as Revealed in Fossils and Subfossils

Advances in Biology, Volume 2014, Issue 1, 2014., 2014
The present work uses fossils and subfossils to decipher the origin and evolution of terrestrial pathogens and endoparasites. Fossils, as interpreted by morphology or specific features of their hosts, furnish minimum dates for the origin of infectious agents, coevolution with hosts, and geographical locations.
George Poinar Jr., Renfu Shao
wiley   +1 more source

Kinetoplast DNA replication: mechanistic differences between Trypanosoma brucei and Crithidia fasciculata. [PDF]

, 1994
Kinetoplast DNA, the mitochondrial DNA of trypanosomatid parasites, is a network containing several thousand minicircles and a few dozen maxicircles.
P T Englund, D C Ward, Ferguson, M L, Perez-Morga, David, Englund, P T, D Pérez-Morga, M L Ferguson, Ward, D C, A F Torri, Torri, A F   +9 more
core   +1 more source

Stunning Intricacies of RNA Editing Complexes RECC, RESC, and REH2C: Functional Organization, Developmental Regulation, and Evolutionary History in Kinetoplastid Protists

WIREs RNA, Volume 17, Issue 2, March/April 2026.
U‐indel RNA editing targets mRNA:gRNA duplexes through three key complexes that collectively govern assembly, specificity, catalysis, and developmental regulation. Modern tools, including artificial intelligence, analyze the organization, dynamics, and evolution of the remarkable holo‐editosome, opening new avenues in RNA biology and therapy.
Suzanne M. McDermott, Julius Lukeš, Laurie K. Read, Reza Salavati, Achim Schnaufer, Sara L. Zimmer, Jason Carnes, Alasdair Ivens, Naghmeh Poorinmohammad, Nicholas J. Savill, Dave Speijer, Ken Stuart, Kristína Záhonová, Poorya Mirzavand Borujeni, Zihao Chen, Cody Goode, Sunil Kumar Sharma, Lars O’Hara, Jorge Cruz‐Reyes   +18 more
wiley   +1 more source

First Report of Trypanosoma sp. in Spectacled Caiman (Caiman crocodilus): Morphological and Phylogenetic Relationships

International Scholarly Research Notices, Volume 2013, Issue 1, 2013., 2013
In Crocodylidae family three trypanosomes species were described, T. grayi in African crocodilian and T. cecili and Trypanosoma sp. in Caimans species from Brazil. T. grayi was transmitted by tsetse flies and the vector of Brazilian caimans trypanosomes is unknown.
Arlei Marcili, Andrea P. da Costa, Herbert S. Soares, Igor C. L. Acosta, Julia T. R. de Lima, Antonio H. H. Minervino, Solange M. Gennari, D. Cone, A. Jabbar, G. Mkoji, P. Somboon   +10 more
wiley   +1 more source

Genomic and phylogenetic evidence of VIPER retrotransposon domestication in trypanosomatids

Memorias do Instituto Oswaldo Cruz
Transposable elements are important residents of eukaryotic genomes and eventually the host can domesticate them to serve cellular functions.
Adriana Ludwig, Marco Aurelio Krieger
doaj   +1 more source

Expression and subcellular localization of kinetoplast-associated proteins in the different developmental stages of Trypanosoma cruzi

BMC Microbiology, 2009
Background The kinetoplast DNA (kDNA) of trypanosomatids consists of an unusual arrangement of circular molecules catenated into a single network. The diameter of the isolated kDNA network is similar to that of the entire cell.
Cavalcanti Danielle, Shimada Márcia, Probst Christian, Souto-Padrón Thais, de Souza Wanderley, Goldenberg Samuel, Fragoso Stênio, Motta Maria   +7 more
doaj   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, Volume 293, Issue 6, Page 1681-1707, March 2026.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Flagellar Motility of Trypanosoma cruzi Epimastigotes

BioMed Research International, Volume 2012, Issue 1, 2012., 2012
The hemoflagellate Trypanosoma cruzi is the causative agent of American trypanosomiasis. Despite the importance of motility in the parasite life cycle, little is known about T. cruzi motility, and there is no quantitative description of its flagellar beating.
G. Ballesteros-Rodea, M. Santillán, S. Martínez-Calvillo, R. Manning-Cela, Abhay R. Satoskar   +4 more
wiley   +1 more source

Pteridines and the Nutrition of the Protozoon Crithidia fasciculata.

Experimental Biology and Medicine, 1955
SummaryThe Trypanosomid flagellate Crithidia fasciculata was found to have a growth requirement for certain 6-substituted pteridines. The most active compound studied was 2-amino-4-hydroxy-6 (1′, 2′-dihydroxy-propyl) pteridine (“biopterin”) which was isolated from human urine. A requirement for both pteroylglutamic acid and an appropriate pteridine was
H P, BROQUIST, A M, ALBRECHT
openaire   +2 more sources