Results 31 to 40 of about 1,687 (191)
The putative Leishmania telomerase RNA (LeishTER) undergoes trans-splicing and contains a conserved template sequence. [PDF]
PLoS ONE, 2014 Telomerase RNAs (TERs) are highly divergent between species, varying in size and sequence composition. Here, we identify a candidate for the telomerase RNA component of Leishmania genus, which includes species that cause leishmaniasis, a neglected ...
Elton J R Vasconcelos +5 more
doaj +1 more source
Broadening the spectrum of ivermectin: Its effect on Trypanosoma cruzi and related trypanosomatids
Frontiers in Cellular and Infection Microbiology, 2022 Chagas disease is an endemic American parasitosis, caused by Trypanosoma cruzi. The current therapies, benznidazole (BZN) and nifurtimox (NFX), show limited efficacy and multiple side effects. Thus, there is a need to develop new trypanocidal strategies.
Laura Fraccaroli +6 more
doaj +1 more source
Actin expression in trypanosomatids (Euglenozoa: Kinetoplastea)
Memorias do Instituto Oswaldo Cruz, 2013 Heteroxenic and monoxenic trypanosomatids were screened for the presence of actin using a mouse polyclonal antibody produced against the entire sequence of the Trypanosoma cruzi actin gene, encoding a 41.9 kDa protein.
Ligia Cristina Kalb Souza +4 more
doaj +1 more source
In silico analysis of the HSP90 chaperone system from the African trypanosome, Trypanosoma brucei
Frontiers in Molecular Biosciences, 2022 African trypanosomiasis is a neglected tropical disease caused by Trypanosoma brucei (T. brucei) and spread by the tsetse fly in sub-Saharan Africa. The trypanosome relies on heat shock proteins for survival in the insect vector and mammalian host.
Miebaka Jamabo +5 more
doaj +1 more source
Stressful Situations: Investigating Cell Death Pathways in Protozoal Parasite Crithidia fasciculata
, 2021 Protozoa of the Class Kinetoplastida include clinically-relevant pathogens such as Leishmania and Trypanosoma. Although specific mechanisms or biological significance of programmed cell death (PCD) have yet to be established in these organisms ...
Ho, Andrew
core +2 more sources
The superfamily keeps growing: Identification in trypanosomatids of RibJ, the first riboflavin transporter family in protists. [PDF]
PLoS Neglected Tropical Diseases, 2017 BACKGROUND:Trypanosomatid parasites represent a major health issue affecting hundreds of million people worldwide, with clinical treatments that are partially effective and/or very toxic.
Darío E Balcazar +6 more
doaj +1 more source
FEBS Open Bio, Volume 9, Issue 10, Page 1769-1783, October 2019., 2019 Tyrosine aminotransferase (TAT) catalyzes the transamination of aromatic amino acids using PLP co‐factor. In this study, TAT from L. donovani was cloned into pET28a(+) vector, expressed, purified, and biochemically characterized. The broad‐specific tyrosine aminotransferase was found to exhibit highest activity at 50 °C and pH 8.
Santanu Sasidharan, Prakash Saudagar
wiley +1 more source
Scanning, Volume 2018, Issue 1, 2018., 2018 The kinetoplast is a specialized region of the mitochondria of trypanosomatids that harbors the most complex and unusual mitochondrial DNA found in nature. Kinetoplast DNA (kDNA) is composed of thousands of circular molecules topologically interlocked to form a single network. Two types of DNA circles are present in the kinetoplast: minicircles (0.5–10
Danielle Pereira Cavalcanti +2 more
wiley +1 more source
Apoptosis in Crithidia fasciculata
, 2021 Crithidia fasciculata belongs to a group of parasites called kinetoplastids that comprise many important human pathogens. Evidence of apoptosis has been found in these parasites with pathways that appear to be different than in mammalian cells. Therefore,
Parker, Kaelynn, Delapenha, Abigail
core +1 more source
Synergistic effects of floral phytochemicals against a bumble bee parasite
Ecology and Evolution, Volume 7, Issue 6, Page 1836-1849, March 2017., 2017 Phytochemical mixtures are ubiquitous in plant species and communities. At a time when many pollinators are suffering disease‐related decline, our study shows that a combination of two floral phytochemicals synergistically inhibits the growth of a parasite of bumble bees.
Evan C. Palmer‐Young +3 more
wiley +1 more source