Results 91 to 100 of about 1,596,370 (315)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Existence of solutions for critical Henon equations in hyperbolic spaces

Electronic Journal of Differential Equations, 2013
In this article, we use variational methods to prove that for a suitable value of $lambda$, the problem $$displaylines{ -Delta_{mathbb{B}^N}u=(d(x))^{alpha}|u|^{2^{*}-2}u+lambda u, quad ugeq 0,quad uin H_0^1(Omega') }$$ possesses at least one non ...
Haiyang He, Jing Qiu
doaj  

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Critical epitaxial thicknesses for low-temperature (20–100 °C) Ge(001)2×1 growth by molecular-beam epitaxy [PDF]

, 1993
G. Xue, H. Z. Xiao, M. Arif Hasan, J. E. Greene, H.K. Birnbaum   +4 more
openalex   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

p-Kirchhoff type problem with a general critical nonlinearity

Electronic Journal of Differential Equations, 2018
In this article, we consider the p-Kirchhoff type problem $$ \Big(1+\lambda\int_{\mathbb{R}^N}|\nabla u|^p +\lambda b\int_{\mathbb{R}^N}|u|^p\Big)(-\Delta_p u+b|u|^{p-2}u) =f(u), x\in\mathbb{R}^N, $$ where $\lambda>0$, the nonlinearity f can reach ...
Huixing Zhang, Baiquan Lin
doaj  

Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression. [PDF]

, 1993
Steven M. Lipkin, Anders M. Näär, K A Kalla, R. Sack, Michael G. Rosenfeld   +4 more
openalex   +1 more source

Critical periods of growth [PDF]

Proceedings of the Nutrition Society, 1976
openaire   +3 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Elliptic equations with one-sided critical growth

Electronic Journal of Differential Equations, 2002
We consider elliptic equations in bounded domains $Omegasubset mathbb{R}^N $ with nonlinearities which have critical growth at $+infty$ and linear growth $lambda$ at $-infty$, with $lambda > lambda_1$, the first eigenvalue of the Laplacian. We prove that
Marta Calanchi, Bernhard Ruf
doaj