Results 91 to 100 of about 11,870,254 (353)

Multi-bump solutions for Schrödinger equation involving critical growth and potential wells

, 2015
In this paper, we consider the following Schrodinger equation with critical growth $$-\Delta u+(\lambda a(x)-\delta)u=|u|^{2^*-2}u \quad \hbox{ in } \mathbb{R}^N, $$ where $N\geq 5$, $2^*$ is the critical Sobolev exponent, $\delta>0$ is a constant, $a(x)
Yuxia Guo, Z. Tang
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Existence of infinitely many solutions for elliptic boundary-value problems with nonsymmetrical critical nonlinearity

Electronic Journal of Differential Equations, 2004
In this paper, we study a semilinear elliptic boundary-value problem involving nonsymmetrical term with critical growth on a bounded smooth domain in $mathbb{R}^n$.
Geng Di
doaj  

Ground State Solutions for Quasilinear Schrödinger Equations with Critical Growth and Lower Power Subcritical Perturbation

Advanced Nonlinear Studies, 2019
We study the following generalized quasilinear Schrödinger equation:
Deng Yinbin, Huang Wentao, Zhang Shen
doaj   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Multiplicity and concentration of positive solutions for fractional nonlinear Schrodinger equations with critical growth

Electronic Journal of Differential Equations, 2019
In this article we consider the multiplicity and concentration behavior of positive solutions for the fractional nonlinear Schrodinger equation $$\displaylines{ \varepsilon^{2s}(-\Delta)^{s}u + V(x)u= u^{2^*_s-1} + f(u) , \quad x\in\mathbb{R}^N ...
Xudong Shang, Jihui Zhang
doaj  

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Critical quasilinear Schrodinger equation with sign-changing potential

Electronic Journal of Differential Equations, 2016
We study the existence of nontrivial solutions for a class of quasilinear Schrodinger equations in R^N with critical nonlinearity, where the potential is allowed to change signs.
Li-Li Wang, Zhi-Qing Han
doaj  

A critical examination of methods of evaluating vitamin A by means of the growth of rats [PDF]

, 1928
Eleanor Margaret Hume, Hannah Henderson Smith   +1 more
openalex   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source