Results 11 to 20 of about 429,240 (119)

Redefining critical illness

Nature Medicine, 2022
Research and practice in critical care medicine have long been defined by syndromes, which, despite being clinically recognizable entities, are, in fact, loose amalgams of heterogeneous states that may respond differently to therapy. Mounting translational evidence-supported by research on respiratory failure due to severe acute respiratory syndrome ...
Maslove, David M, Tang, Benjamin, Shankar-Hari, Manu, Lawler, Patrick R, Angus, Derek C, Baillie, J Kenneth, Baron, Rebecca M, Bauer, Michael, Buchman, Timothy G, Calfee, Carolyn S, Dos Santos, Claudia C, Giamarellos-Bourboulis, Evangelos J, Gordon, Anthony C, Kellum, John A, Knight, Julian C, Leligdowicz, Aleksandra, McAuley, Daniel F, McLean, Anthony S, Menon, David K, Meyer, Nuala J, Moldawer, Lyle L, Reddy, Kiran, Reilly, John P, Russell, James A, Sevransky, Jonathan E, Seymour, Christopher W, Shapiro, Nathan I, Singer, Mervyn, Summers, Charlotte, Sweeney, Timothy E, Thompson, B Taylor, Van Der Poll, Tom, Venkatesh, Balasubramanian, Walley, Keith R, Walsh, Timothy S, Ware, Lorraine B, Wong, Hector R, Zador, Zsolt E, Marshall, John C   +38 more
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Statins in the critically ill [PDF]

Annals of Intensive Care, 2012
The use or misuse of statins in critically ill patients recently attracted the attention of intensive care clinicians. Indeed, statins are probably the most common chronic treatment before critical illness and some recent experimental and clinical data demonstrated their beneficial effects during sepsis, acute lung injury (ALI)/acute respiratory ...
De Loecker, Isabelle, Preiser, Jean-Charles   +1 more
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Immunomodulation in the critically ill [PDF]

British Journal of Anaesthesia, 2009
Immunotherapy in the critically ill is an appealing notion because of the apparent abnormal immune and inflammatory responses seen in so many patients. The administration of a medication that could alter immune responses and decrease mortality in patients with sepsis could represent a 'magic bullet'.
Helen F. Galley, Nigel R. Webster
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Chronic Critical Illness [PDF]

American Journal of Respiratory and Critical Care Medicine, 2010
Although advances in intensive care have enabled more patients to survive an acute critical illness, they also have created a large and growing population of chronically critically ill patients with prolonged dependence on mechanical ventilation and other intensive care therapies.
Aluko A. Hope, Judith E. Nelson, Christopher E. Cox, Shannon S. Carson   +3 more
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Interventions for preventing critical illness polyneuropathy and critical illness myopathy [PDF]

Cochrane Database of Systematic Reviews, 2007
Critical illness polyneuro-and/or myopathy (CIP/CIM) is an important and frequent complication in the intensive care unit (ICU), causing delayed weaning from mechanical ventilation. It may increase ICU stay and mortality.To examine the ability of any intervention to prevent the occurrence of CIP/CIM.We searched the Cochrane Neuromuscular Disease Group ...
Hermans, Greet, De Jonghe, Bernard, Bruyninckx, Frans, Van den Berghe, Greet   +3 more
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Nonthyroidal illness in critically ill children [PDF]

Current Opinion in Endocrinology, Diabetes & Obesity, 2019
Purpose of review This review summarizes recent literature on nonthyroidal illness syndrome (NTI) and outcome of pediatric critical illness, to provide insight in pathophysiology and therapeutic implications. Recent findings NTI is typically characterized by lowered triiodothyronine
Jacobs, An, Vanhorebeek, Ilse, Van den Berghe, Greet   +2 more
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Thrombocytopaenia in the critically ill.

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2021
publishedVersion
Bruserud, Øyvind, Mosevoll, Knut Anders, Kristoffersen, Einar Klæboe, Kvåle, Reidar, Reikvam, Håkon   +4 more
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Antioxidants in Critical Illness [PDF]

Archives of Surgery, 2001
Oxidative stress has been implicated in the manifestations of critical illnesses, including ischemia and reperfusion injury and systemic inflammatory states. This review describes the evidence for increased oxidative stress in critically ill patients and explores the data regarding antioxidant therapy for these conditions.
Eileen M. Bulger, Ronald V. Maier
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Procalcitonin in Critical Illness

Critical Care and Resuscitation, 2001
To detail the biology and diagnostic usefulness of serum procalcitonin in critical illness.A review of articles published in peer reviewed journals from 1990 to 2001 and identified through a MEDLINE search on procalcitonin.Procalcitonin (PCT) is a prohormone of calcitonin.
E, O'Connor, B, Venkatesh, J, Lipman, C, Mashongonyika, J, Hall   +4 more
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The microbiome and critical illness [PDF]

The Lancet Respiratory Medicine, 2016
The central role of the microbiome in critical illness is supported by a half century of experimental and clinical study. The physiological effects of critical illness and the clinical interventions of intensive care substantially alter the microbiome.
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