Results 91 to 100 of about 38,429 (312)

ROS‐induced modifications of fibrin clots connect immune responses to atherothrombosis in systemic lupus erythematosus

open access: yesArthritis &Rheumatology, Accepted Article.
Objective Cardiovascular events are major determinants of morbidity and mortality in systemic lupus erythematosus (SLE), particularly in patients with renal involvement. While oxidative stress has been implicated in driving vascular and renal damage in SLE, the specific mechanisms remain unclear.
Matteo Becatti   +13 more
wiley   +1 more source

An experimental medicine protocol for exploring the haemodynamic effects of dual agonism at the glucagon‐like peptide‐1 and glucagon receptor in healthy subjects

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Glucagon‐like peptide‐1 (GLP‐1) and glucagon dual receptor agonists are in clinical development for a range of metabolic conditions, including type 2 diabetes and obesity. The cardiovascular actions at these receptors are well studied, but less is known about their combination.
James Goodman   +13 more
wiley   +1 more source

Noninvasive Multimodal Imaging to Predict Recovery of Locomotion after Extended Limb Ischemia.

open access: yesPLoS ONE, 2015
Acute limb ischemia is a common cause of morbidity and mortality following trauma both in civilian centers and in combat related injuries. Rapid determination of tissue viability and surgical restoration of blood flow are desirable, but not always ...
Jason S Radowsky   +6 more
doaj   +1 more source

Optimizing biophysical properties of cellular niches to enhance stem cell‐derived extracellular vesicle function in musculoskeletal regeneration

open access: yesBMEMat, EarlyView.
Extracellular vesicles (EVs) derived from stem cells show promise for applications in regenerative medicine, but their scalability and yield remain challenges. This review explores the approaches for biophysical modulations within cell niches on EV properties, discusses the current clinical application of EVs, and provides an outlook on the existing ...
Yang Xu   +9 more
wiley   +1 more source

Critical limb ischemia: current challenges and future prospects

open access: yesVascular Health and Risk Management, 2018
Luigi Uccioli,1 Marco Meloni,1 Valentina Izzo,1 Laura Giurato,1 Stefano Merolla,2 Roberto Gandini2 1Department of Systems Medicine, 2Department of Interventional Radiology, Università di Tor Vergata Roma, Rome, Italy Abstract: Critical limb ...
Uccioli L   +5 more
doaj  

Cutting edge strategies for diabetic wound care: Nanotechnology, bioengineering, and beyond

open access: yesBMEMat, EarlyView.
Graphical abstract illustrates the challenges in diabetic wound healing, covering pathophysiology, formulation hurdles, and emerging therapeutic strategies. It highlights the role of hyperglycemia, formulation complexities, and advanced technologies like bioprinting and AI in improving diabetic wound management. Abstract Diabetic wounds affect millions
Usama Ahmad   +8 more
wiley   +1 more source

The Breakthrough Balloon for Critical Limb Ischemia?

open access: yesJournal of the American College of Cardiology, 2011
A true medical breakthrough represents “a sudden advance especially in knowledge or technique” ([1][1]). In the field of vascular medicine, such a breakthrough is welcome, because many of the treatments we have for peripheral artery disease (PAD) are limited.
openaire   +3 more sources

Biocompatible Chemistry: A Plug‐and‐Play Toolbox for Chemical Biology Research

open access: yesChemBioChem, EarlyView.
The “plug‐and‐play” nature of biocompatible chemistry makes it a powerful toolbox for investigating complicated biological systems and producing drug leads for clinical usages. This review summarizes the commonly used biocompatible reactions and the recent advances of their representative applications in chemical biology research, thus highlighting the
Adam R. Lovato, Zeng Lin, Qingfei Zheng
wiley   +1 more source

Successful Revascularization Using Intravascular Ultrasound‐Guided Wiring in Severe Digital Ischemia With Occluded Radial and Ulnar Arteries: A Case Report

open access: yesCatheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT With recent advances in endovascular therapy (EVT), treatment of complex peripheral artery disease, especially below‐the‐knee lesions, has become increasingly feasible using intravascular ultrasound (IVUS)‐guided techniques. However, reports on EVT for critical digital ischemia remain scarce because of its rarity.
Yasuyuki Tsuchida   +6 more
wiley   +1 more source

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