Results 101 to 110 of about 98,922 (352)

Long-Term Outcomes of BMMSC Compared with BMMNC for Treatment of Critical Limb Ischemia and Foot Ulcer in Patients with Diabetes

Cell Transplantation, 2019
We first compared long-term clinical outcomes in treating critical limb ischemia (CLI) and foot ulcer in patients with diabetes between autologous bone marrow mesenchymal stem cell (BMMSC) and bone-marrow-derived mononuclear cell (BMMNC) transplants ...
De-bin Lu, You-zhao Jiang, Wuquan Deng, Yan Zhang, Z. Liang, Qinan Wu, Xiaoyan Jiang, Ling Zhang, F. Gao, Yin Cao, Bing Chen, Yao-ming Xue   +11 more
semanticscholar   +1 more source

Amelioration of Post‐Stroke Edema and Microcirculatory Dysfunction via Targeted AQP4 Inhibition While Preserving the Glymphatic System

Advanced Science, EarlyView.
Compared to untargeted therapy, the targeted nanocarrier, Angiopep‐2‐conjugated Lipid Nanoparticle (A‐LNP) loaded with TGN‐020 (TGN), selectively accumulated in stroke‐injured regions. It suppressed local aquaporin‐4 (AQP4) overexpression, thereby alleviating cerebral edema and hypoperfusion while preserving global glymphatic clearance.
Lei Jin, Zeyu Yang, Boyang Wei, Yu Wu, Longxiang Li, Jiaming Zhou, Xin Zhang, Fa Jin, Shixing Su, Yanchao Liu, Ran Li, Shenquan Guo, Xingwu Liu, Yu Cai, Hong Liu, Min Chen, Wenchao Liu, Chuanzhi Duan, Xifeng Li   +18 more
wiley   +1 more source

Critical limb ischemia.

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 1996
Chronic critical limb ischemia is defined as ischemia which generally endangers the distal part of a limb. If the ischemia is unrelenting, there is a high risk that amputation will be required. These critical limbs were amputated as an initial treatment long ago.
openaire   +2 more sources

Regenerative Medicine in Critical Limb Ischemia

Journal of Atherosclerosis and Thrombosis, 2012
Critical limb ischemia (CLI) is commonly caused by atherosclerotic arterial obstruction or stenosis in the leg, as demonstrated by rest pain, skin ulcers and gangrene (Fontaine III or IV), often fails to respond to conservative treatments, and carries a high risk for limb amputation, with a particularly dismal prognosis.
Takayuki, Ohno, Hideaki, Kaneda, Yoji, Nagai, Masanori, Fukushima   +3 more
openaire   +3 more sources

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Critical Limb Ischemia as a Consequence of Multiple Spontaneous Arteriovenous Fistulas and Peripheral Arterial Disease

, 2021
Yutaro Yamashita, Hiroyuki Yamasaki, Shinji Nagasaka, Kazuhide Mineda, Soshi Ishida, Yoshiro Abe, Ichiro Hashimoto   +6 more
openalex   +2 more sources

Critical Limb Ischemia: Advanced Medical Therapy [PDF]

Methodist DeBakey Cardiovascular Journal, 2012
Systemic atherosclerosis and its risk factors are present in the majority of patients with critical limb ischemia. Aggressive medical therapy is an immediate and necessary part of the work-up and management of these patients and will involve a multidisciplinary approach. Risk stratification based on a patient's current clinical cardiovascular condition
openaire   +2 more sources

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

TIE2‐expressing monocytes/macrophages regulate revascularization of the ischemic limb

EMBO Molecular Medicine, 2013
A third of patients with critical limb ischemia (CLI) will eventually require limb amputation. Therapeutic neovascularization using unselected mononuclear cells to salvage ischemic limbs has produced modest results.
Ashish S. Patel, Alberto Smith, Silvia Nucera, Daniela Biziato, Prakash Saha, Rizwan Q. Attia, Julia Humphries, Katherine Mattock, Steven P. Grover, Oliver T. Lyons, Luca G. Guidotti, Richard Siow, Aleksandar Ivetic, Stuart Egginton, Matthew Waltham, Luigi Naldini, Michele De Palma, Bijan Modarai   +17 more
doaj   +1 more source

Worse Limb Prognosis for Indirect versus Direct Endovascular Revascularization only in Patients with Critical Limb Ischemia Complicated with Wound Infection and Diabetes Mellitus [PDF]

, 2013
Osamu Iida, Mitsuyoshi Takahara, Yoshimitsu Soga, Yasutaka Yamauchi, Keisuke Hirano, Junichi Tazaki, T. Yamaoka, Nobuhiro Suematsu, Kenji Suzuki, Yoshiaki Shintani, Yusuke Miyashita, Masaaki Uematsu   +11 more
openalex   +1 more source