Results 11 to 20 of about 88,305 (355)

Therapeutic angiogenesis for patients with no-option critical limb ischemia by adipose-derived regenerative cells: TACT-ADRC multicenter trial

Angiogenesis, 2022
Patients with critical limb ischemia (CLI) still have a high rate of lower limb amputation, which is associated with not only a decrease in quality of life but also poor life prognosis.
Yuuki Shimizu, Kazuhisa Kondo, R. Hayashida, Ken-ichiro Sasaki, Masanori Ohtsuka, Y. Fukumoto, S. Takashima, O. Inoue, S. Usui, M. Takamura, M. Sakuma, Teruo Inoue, Tokuichiro Nagata, Y. Akashi, Yoshihiro Yamada, Tamon Kato, K. Kuwahara, Kaoru Tateno, Yoshio Kobayashi, R. Shibata, T. Murohara, Akio Keisuke Yuzuru Kimihiro Yuta Takahiro Kensuke Hide Kodama Takanari Kamei Komori Ishizaki Yoshikawa Ki, A. Kodama, K. Takanari, Y. Kamei, K. Komori, Yuta Ishizaki, T. Yoshikawa, K. Kiyokawa, H. Rikimaru, H. Otsuka, Takashi Kudo, H. Shimomura, Y. Fujimoto, T. Nakayama, H. Kitahara, Y. Kubota, N. Mitsukawa, Shinsuke Akita, S. Ebisawa   +39 more
semanticscholar   +1 more source

Mesenchymal stem cells for critical limb ischemia: their function, mechanism, and therapeutic potential

Stem cell research & therapeutics, 2022
Peripheral arterial disease is atherosclerotic occlusive disease of the lower extremity arteries and afflicts hundreds of millions of individuals worldwide. Its most severe manifestation is chronic limb-threatening ischemia (Petersen et al.
L. L. Lozano Navarro, Xueyi Chen, Lady Tatiana Giratá Viviescas, A. K. Ardila-Roa, María Luna-González, C. Sossa, M. Arango-Rodríguez   +6 more
semanticscholar   +1 more source

Current Status of Angiogenic Cell Therapy and Related Strategies Applied in Critical Limb Ischemia

International Journal of Molecular Sciences, 2021
Critical limb ischemia (CLI) constitutes the most severe form of peripheral arterial disease (PAD), it is characterized by progressive blockade of arterial vessels, commonly correlated to atherosclerosis.
Lucía Beltrán-Camacho, Marta Rojas-Torres, M. Durán-Ruiz   +2 more
semanticscholar   +1 more source

Comparative analysis of mouse bone marrow and adipose tissue mesenchymal stem cells for critical limb ischemia cell therapy

Stem cell research & therapeutics, 2021
Introduction Critical limb ischemia (CLI) is the most advanced form of peripheral arterial disease (PAD) characterized by ischemic rest pain and non-healing ulcers.
Pegah Nammian, S. Asadi-Yousefabad, Sajad Daneshi, M. Sheikhha, S. Tabei, V. Razban   +5 more
semanticscholar   +1 more source

Contemporary Trends in Hospital Admissions and Outcomes in Patients With Critical Limb Ischemia: An Analysis From the National Inpatient Sample Database.

Circulation. Cardiovascular Quality and Outcomes, 2021
BACKGROUND Critical limb ischemia (CLI) morbidity and mortality rates have historically been disproportionately higher than for other atherosclerotic diseases, however, recent trends have not been reported.
Mahesh Anantha-Narayanan, R. Doshi, Krunalkumar Patel, A. Sheikh, Fiorella Llanos-Chea, J. Abbott, M. Shishehbor, R. Guzman, W. Hiatt, S. Duval, Carlos I Mena-Hurtado, K. Smolderen   +11 more
semanticscholar   +1 more source

Autologous Peripheral Blood Mononuclear Cells for Limb Salvage in Diabetic Foot Patients with No-Option Critical Limb Ischemia

Journal of Clinical Medicine, 2021
Peripheral blood mononuclear cells (PBMNCs) are reported to prevent major amputation and healing in no-option critical limb ischemia (NO-CLI). The aim of this study is to evaluate PBMNC treatment in comparison to standard treatment in NO-CLI patients ...
A. Scatena, P. Petruzzi, F. Maioli, F. Lucaroni, C. Ambrosone, G. Ventoruzzo, F. Liistro, D. Tacconi, Marianna Di Filippi, Nico Attempati, L. Palombi, L. Ercolini, L. Bolognese   +12 more
semanticscholar   +1 more source

Autologous cell therapy in diabetes‑associated critical limb ischemia: From basic studies to clinical outcomes (Review).

International Journal of Molecular Medicine, 2021
Cell therapy is becoming an attractive alternative for the treatment of patients with no‑option critical limb ischemia (CLI). The main benefits of cell therapy are the induction of therapeutic angiogenesis and neovascularization that lead to an increase ...
A. Magenta, M. C. Florio, M. Ruggeri, S. Furgiuele   +3 more
semanticscholar   +1 more source

Free Flap Salvage in the Ischemic Foot: A Case Report

Archives of Plastic Surgery, 2022
We performed distal bypass and free flap transfer in a single-stage operation to repair an extensive soft tissue defect in an ischemic foot of an 84-year-old woman.
Dongkyung Seo, Yutaka Dannnoura, Riku Ishii, Keisuke Tada, Kunihiro Kawashima, Tetsunori Yoshida, Katsumi Horiuchi   +6 more
doaj   +1 more source

Bmal1 Downregulation Worsens Critical Limb Ischemia by Promoting Inflammation and Impairing Angiogenesis

Frontiers in Cardiovascular Medicine, 2021
Critical limb ischemia (CLI) is the most advanced clinical stage of peripheral vascular disease with high mobility and mortality. CLI patients suffer from lower extremity rest pain, ulceration, and gangrene caused by insufficient blood and oxygen supply.
Lirong Xu, Yutong Liu, Qianyun Cheng, Yang Shen, Ye Yuan, Xiaolang Jiang, Xu Li, D. Guo, Jun‐hao Jiang, Chang-po Lin   +9 more
semanticscholar   +1 more source

Crossing complex infrapopliteal lesions utilizing a front-end cutting technique: A report of two cases with a novel rotational atherectomy device

SAGE Open Medical Case Reports, 2023
Critical limb ischemia represents the most severe stage of peripheral vascular disease and patients often present with complex, calcified infrapopliteal lesions.
Siddhartha Rao, Anton Hnatov, Trisha Tarra, Amber Amparo, Mallika Bhargava   +4 more
doaj   +1 more source