Results 91 to 100 of about 457,166 (295)

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Three Ontologies to Define Phenotype Measurement Data

Frontiers in Genetics, 2012
There is an increasing need to integrate phenotype measurement data across studies for both human studies and those involving model organisms. Current practices allow researchers to access only those data involved in a single experiment or multiple ...
Mary eShimoyama, Mary eShimoyama, Rajni eNigam, Leslie Sanders McIntosh, Rakesh eNagarajan, Treva K Rice, D.C. eRao, Melinda R. Dwinell, Melinda R. Dwinell   +8 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

ESTUDOS ORGANIZACIONAIS E FILOSOFIA: A CONTRIBUIÇÃO DE DELEUZE [PDF]

RAE: Revista de Administração de Empresas, 2016
This paper aims to examine some of the contributions of Deleuzian Philosophy to Organization Studies. To do so, first I will do a general reading of his work, examining three landmarks of his philosophy: his concept of difference and its implications ...
Maria Fernanda Rios Cavalcanti
doaj  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Matching biomedical ontologies through compact differential evolution algorithm

Systems Science & Control Engineering, 2019
Although biomedical ontologies have been widely used in the life science domain, the heterogeneous problem among biomedical ontologies hampers their inter-operability.
Xingsi Xue, Junfeng Chen
doaj   +1 more source

Marx and the Triple Ontological Criticism

, 2021
The text in question aims to outline the triple ontological criticism that marks the “Marxian turn” in the work of Karl Marx. The article seeks to define the pertinence and evolution of Marxian theory, which has been engaged from a settling of scores against the imputations of idealistic redoubts.
Coelho, Henrique Leão, Sousa, Wesley
openaire   +1 more source

Barriers to the successful exploitation of ERP systems in Chinese state-owned enterprises

, 2010
Adopting a systems perspective, the research presented in this paper aims at identifying, assessing and discussing potential cultural, organisational and system barriers to the successful exploitation of Enterprise Resource Planning (ERP) systems in the ...
Nunes, J.M.B., Peng, G.C.
core   +1 more source

Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou, Carl D. Langefeld, Padmini Sekar, Mary Comeau, Timothy Howard, Tamara N. Kimball, Chen Bowang, Hyacinth I. Hyacinth, Jonathan Rosand, Christopher D. Anderson, Caspar Grond‐Ginsbach, Daniel Woo, Stacie L. Demel   +12 more
wiley   +1 more source