Results 61 to 70 of about 457,166 (295)
Fonamentar la crítica social: de l'enteniment al patiment i viceversa
Digithum, 2019 Aquest article analitza críticament les filosofies socials crítiques de John Dewey i Axel Honneth per tal de ressaltar dues fonts normatives diferents de conflictes socials: l'enteniment científic i el patiment social.
Onni Hirvonen
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Comparison of Mulla Sadra and Roy Bhaskar Ontology: With the Emphasis on the Role of the Concept of ‘Unseen’ [PDF]
اسلام و مطالعات اجتماعی, 2019 Critical realism is a relatively novel approach that has two important claims: first, the outer world exists independently of us, and secondly, knowledge of this world, as it is, is possible.
Emad Afrough, fateme abdollahabadi
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Does Critical Theory Have a Theoretical Obligation to Engage in Social-Ontological Theorisation?
Journal of Social OntologyRecent scholarship on the critical theory of the Frankfurt School and social ontology suggests that the two fields can engage in a mutually enriching dialogue.
Keith Pisani
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(Digital) Media as Critical Pedagogy
Media Theory, 2019 From chalkboard sites to social media, from smartphones to interactive grading software, there is an overabundance of digital learning tools at our fingertips, many of which float into our classrooms on airy praise from university administrators ...
Maximillian Alvarez
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MeLinDa: an interlinking framework for the web of data [PDF]
, 2011 The web of data consists of data published on the web in such a way that they can be interpreted and connected together. It is thus critical to establish links between these data, both for the web of data and for the semantic web that it contributes to ...
Euzenat, Jérôme, Scharffe, François
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Case-based analysis in user requirements modelling for knowledge construction [PDF]
, 2010 Context: Learning can be regarded as knowledge construction in which prior knowledge and experience serve as basis for the learners to expand their knowledge base.
Mushi, Cleopa, Sun, Lily
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Knowledge-based query system for the critical minerals
Applied Computing and GeosciencesCritical minerals are increasingly used in advanced, modern technologies. Exploration for these minerals require efficient mechanisms to search for the latest geological knowledge about the petrogenesis and spatial distribution of these essential ...
Armita Davarpanah +2 more
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