Results 21 to 30 of about 390,617 (266)

Patient-Reported Outcome (PRO) Consortium translation process: consensus development of updated best practices

Journal of Patient-Reported Outcomes, 2018
This paper describes the rationale and goals of the Patient-Reported Outcome (PRO) Consortium’s instrument translation process. The PRO Consortium has developed a number of novel PRO measures which are in the process of qualification by the U.S. Food and
Sonya Eremenco, Sheryl Pease, Sarah Mann, Pamela Berry, on behalf of the PRO Consortium’s Process Subcommittee   +4 more
doaj   +1 more source

A bag-of-paths node criticality measure [PDF]

Neurocomputing, 2018
This work compares several node (and network) criticality measures quantifying to which extend each node is critical with respect to the communication flow between nodes of the network, and introduces a new measure based on the Bag-of-Paths (BoP) framework.
Bertrand Lebichot, Marco Saerens
openaire   +2 more sources

Guidelines for Pediatric Radiotherapy Simulation: A Report From the Children's Oncology Group Radiation Oncology Discipline

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei, Stephen Mihalcik, Sujith Baliga, Young Kwok, Dana Casey, Eric Ehler, Christiane Burton, John C. Breneman, Daphne A. Haas‐Kogan, Suzanne L. Wolden, Arnold C. Paulino, Nadia N. Laack, Natia Esiashvili, Sarah Milgrom, Christine Hill‐Kayser, Thomas J. Fitzgerald, John A. Kalapurakal, Chia‐Ho Hua   +17 more
wiley   +1 more source

How AI Transforms Regulatory Submission: Current Clinical Implementation and Future Prospects

Clinical and Translational Science
Artificial Intelligence (AI) is transforming drug development and regulatory submission by enabling advanced data analytics, predictive modeling and intelligent decision support systems.
Jagdeep T. Podichetty, Anna‐Marika Bauer, Rachel Xu, Nick Henscheid, Wes Anderson, Ayan Khan, Shu Chin Ma, Huong Huynh, Klaus Romero   +8 more
doaj   +1 more source

Non-Small Cell Lung Cancer Symptom Assessment Questionnaire (NSCLC-SAQ): Measurement Properties and Estimated Clinically Meaningful Thresholds From a Phase 3 Study

JTO Clinical and Research Reports, 2022
Introduction: The NSCLC Symptom Assessment Questionnaire (NSCLC-SAQ) was developed to assess NSCLC symptom severity in accordance with Food and Drug Administration evidentiary expectations leading to Food and Drug Administration qualification in 2018 ...
Paul Williams, MPH, Thomas Burke, PharmD, PhD, Josephine M. Norquist, MS, Christina Daskalopoulou, PhD, Rebecca M. Speck, PhD, MPH, Ayman Samkari, MD, Sonya Eremenco, MA, Stephen Joel Coons, PhD   +7 more
doaj   +1 more source

Open Data Revolution in Clinical Research: Opportunities and Challenges

Clinical and Translational Science, 2020
Efforts for sharing individual clinical data are gaining momentum due to a heightened recognition that integrated data sets can catalyze biomedical discoveries and drug development.
Mohamed H. Shahin, Sanchita Bhattacharya, Diego Silva, Sarah Kim, Jackson Burton, Jagdeep Podichetty, Klaus Romero, Daniela J. Conrado   +7 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Literature review to assemble the evidence for response scales used in patient-reported outcome measures

Journal of Patient-Reported Outcomes, 2018
Background In the development of patient-reported outcome (PRO) instruments, little documentation is provided on the justification of response scale selection.
Katharine Gries, Pamela Berry, Magdalena Harrington, Mabel Crescioni, Mira Patel, Katja Rudell, Shima Safikhani, Sheryl Pease, Margaret Vernon   +8 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Real‐world evidence in the cloud: Tutorial on developing an end‐to‐end data and analytics pipeline using Amazon Web Services resources

Clinical and Translational Science
In the rapidly evolving landscape of healthcare and drug development, the ability to efficiently collect, process, and analyze large volumes of real‐world data (RWD) is critical for advancing drug development.
Wes Anderson, Roopal Bhatnagar, Keith Scollick, Marco Schito, Ramona Walls, Jagdeep T. Podichetty   +5 more
doaj   +1 more source