Results 31 to 40 of about 441,995 (314)

How AI Transforms Regulatory Submission: Current Clinical Implementation and Future Prospects

Clinical and Translational Science
Artificial Intelligence (AI) is transforming drug development and regulatory submission by enabling advanced data analytics, predictive modeling and intelligent decision support systems.
Jagdeep T. Podichetty, Anna‐Marika Bauer, Rachel Xu, Nick Henscheid, Wes Anderson, Ayan Khan, Shu Chin Ma, Huong Huynh, Klaus Romero   +8 more
doaj   +1 more source

Open Data Revolution in Clinical Research: Opportunities and Challenges

Clinical and Translational Science, 2020
Efforts for sharing individual clinical data are gaining momentum due to a heightened recognition that integrated data sets can catalyze biomedical discoveries and drug development.
Mohamed H. Shahin, Sanchita Bhattacharya, Diego Silva, Sarah Kim, Jackson Burton, Jagdeep Podichetty, Klaus Romero, Daniela J. Conrado   +7 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Literature review to assemble the evidence for response scales used in patient-reported outcome measures

Journal of Patient-Reported Outcomes, 2018
Background In the development of patient-reported outcome (PRO) instruments, little documentation is provided on the justification of response scale selection.
Katharine Gries, Pamela Berry, Magdalena Harrington, Mabel Crescioni, Mira Patel, Katja Rudell, Shima Safikhani, Sheryl Pease, Margaret Vernon   +8 more
doaj   +1 more source

Assessing asthma symptoms in children: qualitative research supporting the development of the Pediatric Asthma Diary—Child (PAD-C) and Pediatric Asthma Diary—Observer (PAD-O)

Journal of Patient-Reported Outcomes, 2023
Background Pediatric asthma has been identified by regulators, clinicians, clinical trial sponsors, and caregivers as an area in need of novel fit-for-purpose clinical outcome assessments (COAs) developed in accordance with the U.S.
Helena Bradley, Claire Trennery, Amy M. Jones, Aoife Lydon, Frances White, Rebecca Williams-Hall, Rob Arbuckle, Erin Tomaszewski, Vivian H. Shih, John Haughney, Amanda Eisen, Tonya Winders, Stephen Joel Coons, Sonya Eremenco, the Patient-Reported Outcome Consortium’s Pediatric Asthma Working Group   +14 more
doaj   +1 more source

Internet?s critical path horizon [PDF]

The European Physical Journal B - Condensed Matter, 2004
Internet is known to display a highly heterogeneous structure and complex fluctuations in its traffic dynamics. Congestion seems to be an inevitable result of user's behavior coupled to the network dynamics and it effects should be minimized by choosing appropriate routing strategies.
Valverde, Sergi, Sole, Ricard V.
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The Critical Path

American Journal of Islam and Society, 2000
Contemporary Islamic scholarship emerged in the mid-nineteenth centuryin response to the overall stagnation of Muslim society and culture.Muslim reformers advanced a simple but powerful thesis: overcoming theweaknesses and deficiencies of contemporary Muslim society requires profoundsocial and cultural reforms, and hence a critical examination of ...
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Real‐world evidence in the cloud: Tutorial on developing an end‐to‐end data and analytics pipeline using Amazon Web Services resources

Clinical and Translational Science
In the rapidly evolving landscape of healthcare and drug development, the ability to efficiently collect, process, and analyze large volumes of real‐world data (RWD) is critical for advancing drug development.
Wes Anderson, Roopal Bhatnagar, Keith Scollick, Marco Schito, Ramona Walls, Jagdeep T. Podichetty   +5 more
doaj   +1 more source