Results 11 to 20 of about 390,617 (266)

On bounding the delay of a critical path [PDF]

Proceedings of the 2006 IEEE/ACM international conference on Computer-aided design - ICCAD '06, 2006
Process variations cause different behavior of timing-dependent effects across different chips. In this work, we analyze one example of timing-dependent effects, cross-coupling capacitance, and the complex problem space created by considering coupling and process variations together.
Leonard Lee, Li-c. Wang
openaire   +1 more source

Tuberculosis eradication versus control

International Journal of Infectious Diseases, 2017
According to the World Health Organization (WHO), 10.4 million people died of tuberculosis (TB) in 2015, and the disease is now the number one cause of death from a preventable infectious disease worldwide.
Marco Schito, Debra Hanna, Alimuddin Zumla   +2 more
doaj   +1 more source

Empowering drug development: Leveraging insights from imaging technologies to enable the advancement of digital health technologies

Clinical and Translational Science, 2023
The US Food and Drug Administration (FDA) has publicly recognized the importance of improving drug development efficiency, deeming translational biomarkers a top priority.
Elena S. Izmailova, R. Paul Maguire, Timothy J. McCarthy, Martijn L. T. M. Müller, Philip Murphy, Diane Stephenson   +5 more
doaj   +1 more source

Quantitative system pharmacology as a legitimate approach to examine extrapolation strategies used to support pediatric drug development

CPT: Pharmacometrics & Systems Pharmacology, 2022
Extrapolation strategies from adult data for designing pediatric drug development programs are explored using the quantitative systems pharmacology (QSP) modeling approach, a mechanistic drug and disease modeling framework that can predict clinical ...
Karim Azer, Jeffrey S. Barrett
doaj   +1 more source

A Path to Real-World Evidence in Critical Care Using Open-Source Data Harmonization Tools

Critical Care Explorations, 2023
COVID-19 highlighted the need for use of real-world data (RWD) in critical care as a near real-time resource for clinical, research, and policy efforts.
Smith F. Heavner, PhD, RN, Wesley Anderson, PhD, Rahul Kashyap, MBBS, MBA, Pamela Dasher, BA, Ewy A. Mathé, PhD, Laura Merson, Philippe J. Guerin, MD, PhD, Jeff Weaver, MBA, Matthew Robinson, MD, Marco Schito, PhD, Vishakha K. Kumar, MD, MBA, Paul Nagy, PhD   +11 more
doaj   +1 more source

Literature review to characterize the empirical basis for response scale selection in pediatric populations

Journal of Patient-Reported Outcomes, 2018
Background Despite the importance of response option selection for patient-reported outcome measures, there seems to be little empirical evidence for the selected scale type.
April N. Naegeli, Jennifer Hanlon, Katharine S. Gries, Shima Safikhani, Anna Ryden, Mira Patel, Mabel Crescioni, Margaret Vernon   +7 more
doaj   +1 more source

Volumetric MRI-Based Biomarkers in Huntington's Disease: An Evidentiary Review

Frontiers in Neurology, 2021
Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disorder that is caused by expansion of a CAG-repeat tract in the huntingtin gene and characterized by motor impairment, cognitive decline, and neuropsychiatric disturbances ...
Kirsi M. Kinnunen, Adam J. Schwarz, Emily C. Turner, Dorian Pustina, Emily C. Gantman, Mark F. Gordon, Richard Joules, Ariana P. Mullin, Ariana P. Mullin, Rachael I. Scahill, Nellie Georgiou-Karistianis, The Huntington's Disease Regulatory Science Consortium (HD-RSC), Varun Aggarwal, Shazia Ali, Irina Antonijevic, Astri Arnesen, Nazem Atassi, Brian Beers, Beth Belluscio, Limor Ben Har, Angele Benard, Caroline Benn, Brian Bettencourt, Anu Bhattacharyya, Robi Blumenstein, Beth Borowsky, Bret Bostwick, Jackson Burton, Angelika Caputo, David Cooper, Brad Elmer, Rebecca Evans, Andrew Feigen, Terrence Fisher, Rebecca Fuller, Emily Gantman, Danielle Gartner, Michal Geva, Nellie Georgiou-Karistianis, Sandra Gonzalez, Adam Good, Mark Gordon, Jaya Goyal, Michael Hayden, Priyantha Herath, Steve Hersch, Jianying Hu, Elise Kayson, Eileen Koski, Bernhard Landwehrmeyer, Michelle Lax, Blair Leavitt, Dorothy Leong, Oren Levy, Enchi Liu, Jeff Long, Doug Macdonald, Jacqueline Major, Lahar Mehta, Tiago Mestre, Eric Miller, Christian Mueller, Catherine O'Riordan, Jennifer Panagoulias, Mike Panzara, Anne Pedata, Jennifer Petrillo-Billet, Dave Podskalny, Alisha Reader, Shelly Redman, Ralf Reilmann, Klaus Romero, Christopher Ross, Anne Rosser, Cristina Sampaio, Jan Samzelius, Scott Schobel, Adam Schwarz, Sudhir Sivakumaran, Jennie Socha, Glenn Stebbins, Julie Stout, Sarah Tabrizi, Emily Turner, Charles Venuto, Louise Vetter, Vissia Viglietta, Sarah Wahlstrom Helgren, Beth White, Ed Wild, George Yohrling, Maurice Zauderer   +91 more
doaj   +1 more source

Paths to self-organized criticality [PDF]

Brazilian Journal of Physics, 2000
23 pages + 2 ...
Dickman R, Munoz MA, Vespignani A, Zapperi S   +3 more
openaire   +5 more sources

Thinking Inside the Box: Simple Methods to Evaluate Complex Treatments

Journal of Methods and Measurement in the Social Sciences, 2011
We risk ignoring cheaper and safer medical treatments because they cannot be patented, lack profit potential, require too much patient-contact time, or do not have scientific results. Novel medical treatments may be difficult to evaluate for a variety of
J. Michael Menke
doaj   +1 more source

Metadata Framework to Support Deployment of Digital Health Technologies in Clinical Trials in Parkinson’s Disease

Sensors, 2022
Sensor data from digital health technologies (DHTs) used in clinical trials provides a valuable source of information, because of the possibility to combine datasets from different studies, to combine it with other data types, and to reuse it multiple ...
Derek L. Hill, Diane Stephenson, Jordan Brayanov, Kasper Claes, Reham Badawy, Sakshi Sardar, Katherine Fisher, Susan J. Lee, Anthony Bannon, George Roussos, Tairmae Kangarloo, Viktorija Terebaite, Martijn L. T. M. Müller, Roopal Bhatnagar, Jamie L. Adams, E. Ray Dorsey, Josh Cosman   +16 more
doaj   +1 more source