SMAD4 loss enables EGF, TGFβ1 and S100A8/A9 induced activation of critical pathways to invasion in human pancreatic adenocarcinoma cells. [PDF]
Oncotarget, 2016 Epidermal Growth Factor (EGF) receptor overexpression, KRAS, TP53, CDKN2A and SMAD4 mutations characterize pancreatic ductal adenocarcinoma. This mutational landscape might influence cancer cells response to EGF, Transforming Growth Factor \u3b21 (TGF ...
Moz S +14 more
europepmc +4 more sources
Critical molecular pathways in CLL therapy [PDF]
Molecular Medicine, 2018 Chronic lymphocytic leukemia (CLL), the most frequent type of leukemia in western countries, is characterized by the progressive accumulation in blood, bone marrow and lymphoid tissues of monoclonal B lymphocytes with a characteristic immunophenotype ...
Gerardo Ferrer, Emili Montserrat
doaj +3 more sources
In-hospital mortality in the emergency department: clinical and etiological differences between early and late deaths among patients awaiting admission [PDF]
Clinical and Experimental Emergency Medicine, 2021 Objective Given that there are no studies on diseases that occur by waiting for hospitalization, we aimed to evaluate the main causes of death in the emergency room (ER) and their relationship with overcrowding. Methods Patients who died in the ER in the
Gabriele Valli +8 more
doaj +1 more source
Preoperative clinical management of patients who are candidates for facial transplantation [PDF]
Revista Brasileira de Cirurgia Plástica, 2023 Introduction: Face transplantation has gained recognition, changing the clinicalsurgical scenario for restoring complex facial defects, as it attributes functional and aesthetic recovery to patients who have suffered serious accidents.
Martin Iglesias Morales +3 more
doaj +1 more source
Health Science Reports, 2022 Background and Aims In oncology, there is increasing talk of personalized treatment and shared decision‐making (SDM), especially when multiple treatment options are available with different outcomes depending on patient preference.
Carmen Angioletti +7 more
doaj +1 more source
Management pathway for emergency department patients in the setting of the opioid epidemic and emergency department overcrowding [PDF]
Clinical and Experimental Emergency Medicine, 2020 Objective The United States is currently in the midst of a major opioid addiction epidemic, of which the primary drivers are a sharp increase in prescription opioid pain medications, their misuse, and the inordinate illicit use of opioids.
Kiersten Gurley +3 more
doaj +1 more source
Care Pathway for Cancer Survivorship in Korea: Trend of Breast Cancer Pathway from 2003 to 2010 [PDF]
Healthcare Informatics Research, 2017 ObjectivesThe survival rate of cancer patients has exceeded 60%. Although cancer survivors may die of other diseases except cancer, the health management system including chronic disease prevention-management for cancer survivors, has not been ...
Hwa Jeong Seo, Dong Yong Noh
doaj +1 more source
Nrf2 Activator PB125® as a Potential Therapeutic Agent against COVID-19
Antioxidants, 2020 Nrf2 is a transcription factor that regulates cellular redox balance and the expression of a wide array of genes involved in immunity and inflammation, including antiviral actions.
Joe M. McCord +4 more
doaj +1 more source
Conformance Analysis of Clinical Pathway Using Electronic Health Record Data [PDF]
Healthcare Informatics Research, 2015 ObjectivesThe objective of this study was to confirm the conformance rate of the actual usage of the clinical pathway (CP) using Electronic Health Record (EHR) log data in a tertiary general university hospital to improve the CP by reflecting real-world ...
Sooyoung Yoo +7 more
doaj +1 more source
Revista Panamericana de Salud Pública, 2022 Cardiovascular diseases are the leading cause of mortality and morbidity in the Region of the Americas, and hypertension represents its main risk factor. However, population hypertension control rates in the Region are poor.
Andres Rosende +6 more
doaj +1 more source