Results 91 to 100 of about 2,672,882 (329)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

More through the door: increasing entry to university geoscience education as a means to address the critical minerals skills shortage

Earth Science, Systems and Society
Critical minerals (CMs) supply is vulnerable to a skills shortage. We focus on (1) the UK situation, where suitable training is provided but numbers taking the university courses have dwindled, and (2) routes through geoscience education into CM careers,
K.R. Moore, K.M. Ryan, F. Wall, R.K. Shail, P.J. Foster   +4 more
doaj   +1 more source

White matter pathways critical for language are also critical for resolving proactive interference in working memory

Frontiers in Psychology, 2014
Background White matter pathways connecting brain regions involved in language processing in the left prefrontal (PFC) and temporal cortices have been found to play a critical role in language comprehension (Turken and Dronkers, 2011). Among the frontal
Stephanie Kathleen Ries, Krista Schendel, Nina F Dronkers   +2 more
doaj   +1 more source

Effects of strand and directional asymmetry on base-base coupling and charge transfer in double-helical DNA [PDF]

, 2002
Mechanistic models of charge transfer (CT) in macromolecules often focus on CT energetics and distance as the chief parameters governing CT rates and efficiencies.
Barton, Jacqueline K., O'Neill, Melanie A.   +1 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Implementation and use of technology-enabled remote monitoring for chronic obstructive pulmonary disease: a rapid qualitative evaluation

Health and Social Care Delivery Research
Background Chronic obstructive pulmonary disease affects around 2% United Kingdom population. Timely identification of patients at risk of deterioration is crucial.
Nikki Newhouse, Agne Ulyte, Zuzanna Marciniak-Nuqui, Jackie van Dael, Sonja Marjanovic, Sharon Brennan, Sara Shaw   +6 more
doaj   +1 more source

Single-Cell RNA Sequencing of hESC-Derived 3D Retinal Organoids Reveals Novel Genes Regulating RPC Commitment in Early Human Retinogenesis. [PDF]

, 2019
The development of the mammalian retina is a complicated process involving the generation of distinct types of neurons from retinal progenitor cells (RPCs) in a spatiotemporal-specific manner.
An, Qin, Fan, Guoping, Hu, Youjin, Liu, Qinghuai, Mao, Xiying, Wang, Jinmei, Xi, Huiyu, Yang, Xian-Jie, Yuan, Songtao, Zhang, Xiangmei   +9 more
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Treatments for renal cell carcinoma: NICE Pilot Treatment Pathways Appraisal

Health Technology Assessment
Background The National Institute for Health and Care Excellence is piloting a new approach to evaluating health technologies, which takes into consideration the full treatment pathway for a condition.
Dawn Lee, Madhusubramanian Muthukumar, Alan Lovell, Caroline Farmer, Darren Burns, Justin Matthews, Helen Coelho, Brian O’Toole, Laura A Trigg, Tristan M Snowsill, Maxwell S Barnish, Thalia Nikoglou, Amanda Brand, Zain Ahmad, Ahmed Abdelsabour, Louise Crathorne, Sophie Robinson, Edward CF Wilson, GJ Melendez-Torres   +18 more
doaj   +1 more source

Gene co-expression network identifies critical genes, pathways and regulatory motifs mediating the progression of rift valley fever in Bos taurus [PDF]

, 2023
John Gitau, Rosaline W. Macharia, Kennedy Mwangi, Nehemiah Ongeso, Edwin Murungi   +4 more
openalex   +1 more source