Results 111 to 120 of about 9,005,815 (383)

Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. [PDF]

open access: yes, 2013
Posttranslational modifications play central roles in myriad biological pathways including circadian regulation. We employed a circadian proteomic approach to demonstrate that circadian timing of phosphorylation is a critical factor in regulating ...
Allen, Jasmina J   +10 more
core   +1 more source

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Analysis of literary productions on the use of therapeutic play in clinical child [PDF]

open access: yesRevista Gestão & Saúde, 2012
This study aimed to survey and describe the scientific production on the use of therapeutic play as a resource facilitator in assisting the child during the performance ofclinical procedures by the healthteam.the strategy is through the integrative ...
Dione Viero Viana   +2 more
doaj  

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Barriers to Electrification: Analyzing Critical Delays and Pathways Forward

open access: yesWorld Electric Vehicle Journal
This paper extensively explores the intricate nuances surrounding the delayed transition to new business models for electric vehicles. While there is commendable clarity regarding stakeholders, model possibilities, emission-reduction strategies, state ...
Beatriz Amante García   +1 more
doaj   +1 more source

Editorial: Different pathways into critical whiteness studies [PDF]

open access: yes, 2012
This special issue explores the complexities of critical whiteness studies methodologies. We decided upon critical whiteness studies (CWS) as our nodal point for this special issue since we believe whiteness often stays unchallenged as un-articulated and
Pedersen, Linda, Samaluk, Barbara
core  

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

open access: yesFEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt   +4 more
wiley   +1 more source

Protecting Critical Infrastructure by Identifying Pathways of Exposure to Risk [PDF]

open access: yesTechnology Innovation Management Review, 2013
Increasingly, our critical infrastructure is managed and controlled by computers and the information networks that connect them. Cyber-terrorists and other malicious actors understand the economic and social impact that a successful attack on these ...
Philip O’Neill
doaj  

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

open access: yesFEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel   +2 more
wiley   +1 more source

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