Results 101 to 110 of about 3,581,339 (338)

Multiplicity of Homoclinic Solutions for Fractional Hamiltonian Systems with Subquadratic Potential

open access: yesEntropy, 2017
In this paper, we study the existence of homoclinic solutions for the fractional Hamiltonian systems with left and right Liouville–Weyl derivatives. We establish some new results concerning the existence and multiplicity of homoclinic solutions for the ...
Neamat Nyamoradi   +3 more
doaj   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

open access: yesMolecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed   +8 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Field-Theoretical Analysis of Critical and Coexistence Singularities at Critical End Points

open access: yes, 1999
Continuum models with critical end points are considered whose Hamiltonian ${\mathcal{H}}[\phi,\psi]$ depends on two densities $\phi$ and $\psi$. Field-theoretic methods are used to show the equivalence of the critical behavior on the critical line and ...
Barbosa   +23 more
core   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

Range of semilinear operators for systems at resonance

open access: yesElectronic Journal of Differential Equations, 2012
For a vector function $u:mathbb{R} o mathbb{R}^N $ we consider the system $$displaylines{ u''(t)+ abla G(u(t))= p(t)cr u(t)=u(t+T), }$$ where $G: mathbb{R}^N o mathbb{R}$ is a $C^1$ function.
Pablo Amster, Mariel Paula Kuna
doaj  

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

open access: yesMolecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva   +5 more
wiley   +1 more source

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