Results 71 to 80 of about 3,262,666 (184)

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Multiple Solutions for a Nonlinear Fractional Boundary Value Problem via Critical Point Theory

Journal of Function Spaces, 2017
This paper is concerned with the existence of multiple solutions for the following nonlinear fractional boundary value problem: DT-αaxD0+αux=fx,ux,  x∈0,T, u0=uT=0, where α∈1/2,1, ax∈L∞0,T with a0=ess  infx∈0,Tax>0, DT-α and D0+α stand for the left and ...
Yang Wang, Yansheng Liu, Yujun Cui
doaj   +1 more source

Spin glass transition in a magnetic field: a renormalization group study

, 2002
We study the transition of short range Ising spin glasses in a magnetic field, within a general replica symmetric field theory, which contains three masses and eight cubic couplings, that is defined in terms of the fields representing the replicon ...
A. J. Bray, A.B. Harris, A.J. Bray, A.J. Bray, C. De Dominicis, C. De Dominicis, D. Sherrington, D.S. Fisher, D.S. Fisher, E. Pytte, F. Krzakala, G. Parisi, G. Parisi, G. Parisi, G. Parisi, G. Parisi, I. R. Pimentel, J. Houdayer, J.E. Green, J.R.L. de Almeida, K. Binder, K.G. Wilson, P. Monod, S.F. Edwards, T. Temesvari, T. Temesvári, W.L. McMillan   +26 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Existence of homoclinic orbits for a class of nonlinear functional difference equations

Electronic Journal of Differential Equations, 2016
By using critical point theory, we prove the existence of a nontrivial homoclinic orbit for a class of nonlinear functional difference equations. Our conditions on the nonlinear term do not need to satisfy the well-known global Ambrosetti-Rabinowitz ...
Xia Liu, Tao Zhou, Haiping Shi
doaj  

The Hausdorff dimension of random walks and the correlation length critical exponent in Euclidean field theory

, 1993
We study the random walk representation of the two-point function in statistical mechanics models near the critical point. Using standard scaling arguments we show that the critical exponent $\nu$ describing the vanishing of the physical mass at the ...
C. Itzykson, D. J. Amit, Joe Kiskis, Pavlos Vranas, Rajamani Narayanan   +4 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Criticality in Third Order Lovelock Gravity and the Butterfly effect

, 2017
We study third order Lovelock Gravity in $ D=7 $ at the critical point which three (A)dS vacua degenerate into one. We see there is not propagating graviton at the critical point. And also we compute the butterfly velocity for this theory at the critical
Qaemmaqami, Mohammad M.
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Mixed boundary value problems involving Sturm–Liouville differential equations with possibly negative coefficients

Boundary Value Problems
This paper is devoted to the study of a mixed boundary value problem for a complete Sturm–Liouville equation, where the coefficients can also be negative. In particular, the existence of infinitely many distinct positive solutions to the given problem is
Gabriele Bonanno, Giuseppina D’Aguì, Valeria Morabito   +2 more
doaj   +1 more source