Results 81 to 90 of about 3,262,666 (184)

Morse Thoery of Saddle Point Reduction with Applications

Axioms
In this paper, we demonstrate that when saddle point reduction is applicable, there is a clear relationship between the Morse index and the critical groups before and after the reduction.
Ran Yang, Qin Xing
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Existence of uncountably many periodic solutions for second-order superlinear difference equations with continuous time

Bulletin of Mathematical Sciences
Due to the essential difficulty of establishing an appropriate variational framework on a suitable working space, how to apply the critical point theory for showing the existence and multiplicity of periodic solutions of continuous-time difference ...
Genghong Lin, Zhan Zhou, Zupei Shen, Jianshe Yu   +3 more
doaj   +1 more source

Field-Theoretical Analysis of Critical and Coexistence Singularities at Critical End Points

, 1999
Continuum models with critical end points are considered whose Hamiltonian ${\mathcal{H}}[\phi,\psi]$ depends on two densities $\phi$ and $\psi$. Field-theoretic methods are used to show the equivalence of the critical behavior on the critical line and ...
Barbosa, Barbosa, Berker, Blume, Brézin, Fisher, Fisher, Fisher, Fisher, Griffiths, Groh, H.W. Diehl, Halperin, Kaufman, M. Smock, Nienhuis, Roux, Sivardière, Widom, Widom, Wilding, Wilding, Wilding, Ziman   +23 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Periodic solutions for second order delay Duffing equation via critical point theory

Electronic Journal of Differential Equations, 2013
This article concerns the periodic problem of second order delay Duffing equation with cross resonance condition. Using critical point theory and homotopy methods, we obtain sufficient conditions for the existence of periodic solutions.
Jingrui Zhang, Yi Cheng, Changqin Yuan
doaj  

Quantum Electrodynamics in d=3 from the epsilon-expansion

, 2015
We study Quantum Electrodynamics in d=3 (QED_3) coupled to N_f flavors of fermions. The theory flows to an IR fixed point for N_f larger than some critical number N_f^c.
Di Pietro, Lorenzo, Komargodski, Zohar, Shamir, Itamar, Stamou, Emmanuel   +3 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Multiplicity of Homoclinic Solutions for Fractional Hamiltonian Systems with Subquadratic Potential

Entropy, 2017
In this paper, we study the existence of homoclinic solutions for the fractional Hamiltonian systems with left and right Liouville–Weyl derivatives. We establish some new results concerning the existence and multiplicity of homoclinic solutions for the ...
Neamat Nyamoradi, Ahmed Alsaedi, Bashir Ahmad, Yong Zhou   +3 more
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source