Results 81 to 90 of about 11,237,275 (282)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Regulatory framework for polymer-based nanotherapeutics in clinical translation

Frontiers in Bioengineering and Biotechnology
Polymer-based nanotherapeutics (PNs) have emerged as versatile drug delivery platforms offering controlled release, targeted delivery, and improved pharmacokinetics across therapeutic areas.
Federico Stucchi, Min Li, Giuseppe Castellano, Giuseppe Castellano, Francesco Cellesi   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Interaction Between Food Attributes in Markets: The Case of Environmental Labeling [PDF]

Some consumers derive utility from using products produced with specific processes, such as environmentally friendly practices. Means of verifying these credence attributes, such as certification, are necessary for the market to function effectively.
Grolleau, Gilles, Caswell, Julie A.
core  

System Performance Check (SPC): A Readiness Companion to Multi-Attribute Method (MAM) Analysis in Biopharmaceutical Quality Control

Pharmaceuticals
Background/Objectives: The multi-attribute method (MAM) is a powerful LC-MS workflow for site-specific monitoring of critical quality attributes (CQAs) in biopharmaceutical products, but its sensitivity to LC drift, ionization variability, and mass ...
Jahziel Chase, Melissa Sato, Gordon Slysz, Mahsan Miladi, Mike Knierman, Robert Barkovich, Jared Auclair   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Critical quality indicators of higher education

, 2017
This study explores the weakest total quality management dimensions and defines the critical quality indicators for Taiwanese universities using a hybrid model using importance–performance analysis (IPA) and a fuzzy analytic hierarchy process (FAHP). IPA
Chen, I-Shuo, Chen, Jui-Kuei, Padro, Fernando F.   +2 more
core   +1 more source

Critical Quality Attributes of Lipid Nanoparticles for mRNA: Selection, Justification, and Control

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Lipid nanoparticles represent a promising platform for targeted drug delivery, including nucleic acids, as demonstrated by COVID-19 vaccines. Unlike conventional dosage forms, lipid nanoparticles are complex supramolecular systems where the
U. A. Efremova, I. I. Terninko
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source