Results 91 to 100 of about 552,040 (243)

Understanding the Meaning of Traditional Fairy Tales in Contemporary Educational Context

open access: yesAnnales, Series Historia et Sociologia
The aim of this paper is to develop a model for critical reading of traditional fairy tales, which will enable the understanding of their meanings in contemporary educational context from a gender perspective.
Dijana Vučković, Marijan Premović
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

“The Language of the Digital Air”: AI-Generated Literature and the Performance of Authorship

open access: yesHumanities
The release of ChatGPT and similar applications in 2022 prompted wide-ranging discussions concerning the impact of AI technologies on writing, creativity, and authorship. This article explores the question of artificial writing, taking into consideration
Silvana Colella
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Ortaokul Öğrencilerinin Eleştirel Dinleme ve Okuma Özyeterliklerinin İncelenmesi

open access: yesSakarya Üniversitesi Eğitim Fakültesi Dergisi
Ortaokul öğrencilerinin eleştirel dinleme ve okuma özyeterlikleri algıları arasındaki ilişkiyi farklı değişkenler açısından incelemeyi hedefleyen bu çalışmada tarama yöntemi tercih edilmiştir.
Aslı Yağız, Nahide İrem Azizoğlu
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Critical reading and engagement matters: Integrating the flipped 5E inquiry instruction with Socratic seminars

open access: yesStudies in English Language and Education
Despite the breadth of research on EFL reading comprehension, limited attention has been given to teacher support for critical reading and learner engagement in the Thai higher education context.
Raweewat Sripradith   +1 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

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