Results 111 to 120 of about 2,749,760 (285)

Editorial: Should Orthopaedic Residents Be Required to Do Research, or Would Critical Reading Programs Be a Better Use of Their Time? [PDF]

Clin Orthop Relat Res, 2022
Leopold SS.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Designing reading tasks to foster critical thinking Designing reading tasks to foster critical thinking

Ilha do Desterro, 2008
What else is there besides multiple choice exercises, questions or true-false statements? What kind of readers do we EFL/ESL teachers, want to develop? Fortunately, there are alternative possibilities for designing reading activities which, besides being
Leda Maria Braga Tomitch
doaj  

Indonesian EFL Learners' Critical Thinking in Reading: Bridging the Gap Between Declarative, Procedural and Conditional Knowledge [PDF]

, 2019
Critical thinking is explicitly mentioned in many school and university curricula around the world including in the Indonesian education curriculum but it is rarely promoted inside the classrooms.
Mbato, C. L. (Concilianus)
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Pre-service teachers evaluating online texts about learning styles: there is room for improvement in justifying the credibility

Frontiers in Education
Teachers’ abilities to critically evaluate the credibility of online information are fundamental when they educate critical online readers. This study examined pre-service teachers’ abilities to evaluate and justify the credibility of online texts on ...
Pirjo Kulju, Elina K. Hämäläinen, Marita Mäkinen, Eija Räikkönen, Carita Kiili   +4 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Critical reading [PDF]

British Dental Journal, 2007
openaire   +2 more sources

The influence of semantic context on initial eye landing sites in words [PDF]

, 2000
To determine the role of ongoing processing on eye guidance in reading, two studies examined the effects of semantic context on the eyes' initial landing position in words of different levels of processing diffculty.
d'Ydewalle, Géry, Lavigne, Frédéric, Vitu, Françoise   +2 more
core