Results 121 to 130 of about 2,749,760 (285)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Derrida and meaning : the problem of authorial intention : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in English at Massey University [PDF]

, 1985
This thesis examines Jacques Derrida's deconstructive critique of the logocentric concept of meaning and.proposes that Derrida's critique maintains the importance of authorial intention for literary critical practice.
Molloy, Harvey Lees
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Development of a Textbook for Critical Reading of Legal Documents in Compulsory University Courses in Higher Education

Jurnal Kependidikan
This study aims to develop a legal document-based critical reading textbook in compulsory university courses in higher education. This study used a research and development method with the ADDIE model.
Triwati Rahayu, Suryadi Suryadi
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Attractor states, control parameters, and co-adaptation in instructed L2 inferential comprehension: a design-based research study of a critical reading intervention Estados atratores, parâmetros de controle, e co-adaptação no ensino da compreensão inferencial em L2: uma pesquisa design-based de intervenção de leitura crítica

Revista Brasileira de Linguística Aplicada, 2013
Previous L1 and L2 research on inferential comprehension has tended to follow a quantitative orientation. By contrast, L2 research on critical reading is qualitative and tends to ignore inferences. This paper presents a qualitative, design-based study of
Moisés Damián Perales Escudero
doaj  

The Relationship between EFL Learners’ Emotional Intelligence and Critical Reading [PDF]

Journal of Applied Linguistics, 2008
This study examined the EFL learners’ Emotional Quotient (EQ) and Critical Reading (CR) ability to identify possible relationships between these two traits.
Mahnaz Saeidi, Mandana Yusefi
doaj  

[Review of] Arnold Krupat. For Those Who Come After: A Study of Native American Autobiography [PDF]

, 1986
This is the second monograph on Native American autobiography, and together with Bataille and Sands\u27 American Indian Women Telling Their Lives will be the necessary starting point for future studies in this neglected area of American literature.
Jaskoski, Helen
core   +1 more source

The Nine Cancer Frames: A Tool to Facilitate Critical Reading of Cancer-Related Information. [PDF]

J Cancer Educ, 2022
Murray C, von Possel N, Lie HC, Breivik J.   +3 more
europepmc   +1 more source