Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Developing critical reading module using integrated learning content and language approach
, 2020 The purpose of this research is to compile a teaching material in the form of critical reading modules that are effective, valid, and practical for English major students.
Annas Surdyanto, Wiwit Kurniawan
semanticscholar +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Letter to the Editor: Editorial: Should Orthopaedic Residents Be Required to Do Research, or Would Critical Reading Programs Be a Better Use of Their Time? [PDF]
Clin Orthop Relat Res, 2023 Ahn J, Schaffer NE.
europepmc +2 more sources
Journal of Language and Education, 2015 The main aim of the research is to examine professional L1 (Russian)/L2 (English) writing experiences among staff members of one Russian research-intensive university as well as to provide more insights into the universal pedagogies of professional ...
Natalia Smirnova
doaj +1 more source
The Effect of Critical Reading Skills on the Evaluation Skills of the Creative Reading Process
, 2020 Article History: Purpose: To raise authentically creative individuals, it is compulsory to employ contemporary reading methods. Although critical reading, which is the main medium for accessing the right knowledge, is defined as a sub-category for ...
Yasemin Baki
semanticscholar +1 more source
The impact of a critical reading course in the Turkish High School context [PDF]
Recent research, which argues that discourses shape and are shaped by social reality, has contributed to the development of Critical Literacies and Critical Language Awareness in education.
Íçmez, Simla
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Indonesian Undergraduate Students’ Perceptions of Project-Based Learning in Critical Reading Class
, 2020 Along with the increasing popularity of Project-Based Learning (PBL), teachers are aware of the benefits of PBL to implement it in their classroom. The literature has shown that the use of PBL can enhance students' skills, ability, and interest while ...
Arien Kartika
semanticscholar +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source